SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ej0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 MET A  69
LEU A  99
PRO A 155
GLY A 162
 None
 1.02A 1hrkA-2ej0A:
undetectable		 1hrkA-2ej0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.36A 2a1hA-2ej0A:
30.3
2a1hB-2ej0A:
30.2		 2a1hA-2ej0A:
27.85
2a1hB-2ej0A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.29A 2a1hA-2ej0A:
30.3
2a1hB-2ej0A:
30.2		 2a1hA-2ej0A:
27.85
2a1hB-2ej0A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.21A 2coiA-2ej0A:
30.7
2coiB-2ej0A:
31.1		 2coiA-2ej0A:
28.14
2coiB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.26A 2coiA-2ej0A:
30.7
2coiB-2ej0A:
31.1		 2coiA-2ej0A:
28.14
2coiB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		6 / 11 PHE A  36
TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.34A 2cojA-2ej0A:
30.5
2cojB-2ej0A:
30.8		 2cojA-2ej0A:
28.14
2cojB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.25A 2cojA-2ej0A:
30.5
2cojB-2ej0A:
30.8		 2cojA-2ej0A:
28.14
2cojB-2ej0A:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		8 / 8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
 None
None
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
 0.29A 2ej3A-2ej0A:
49.5		 2ej3A-2ej0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		10 / 10 PHE A  36
TYR A  95
ARG A  97
TYR A 164
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
 None
None
None
PMP  A3413 (-4.4A)
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
 0.24A 2ej3B-2ej0A:
48.4		 2ej3B-2ej0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		8 / 8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
 None
None
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
 0.30A 2ej3C-2ej0A:
48.7		 2ej3C-2ej0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLY A  12
ILE A   8
ALA A   5
VAL A  85
ILE A  96
 None
 1.15A 2nnhA-2ej0A:
undetectable		 2nnhA-2ej0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 ALA A 192
GLU A 193
LEU A 141
VAL A 263
ILE A 271
 None
PMP  A3413 (-3.3A)
None
None
None
 1.45A 2uxpA-2ej0A:
undetectable		 2uxpA-2ej0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 THR A 220
THR A 254
LEU A 283
ILE A 207
TYR A  42
 PMP  A3413 (-3.5A)
None
None
None
None
 1.39A 3gwxB-2ej0A:
undetectable		 3gwxB-2ej0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ALA A 139
GLU A 197
GLU A 181
ALA A 258
 None
 1.33A 3r9tC-2ej0A:
undetectable		 3r9tC-2ej0A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLY A 156
ASN A 198
GLU A 193
MET A  69
 None
PMP  A3413 ( 3.7A)
PMP  A3413 (-3.3A)
None
 1.28A 4g0vB-2ej0A:
undetectable		 4g0vB-2ej0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A 240
VAL A 191
LEU A 183
ILE A 266
ILE A 271
 None
 0.94A 5nunA-2ej0A:
undetectable		 5nunA-2ej0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A 183
ALA A 182
LEU A 199
 None
 0.37A 5uunB-2ej0A:
undetectable		 5uunB-2ej0A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ALA A 258
VAL A 224
TYR A 287
 None
 0.63A 5zmqH-2ej0A:
undetectable		 5zmqH-2ej0A:
23.68