SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ej5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 11 LEU A 158
LEU A 148
LEU A 145
ILE A 134
GLY A 164
 None
 1.28A 1g50C-2ej5A:
undetectable		 1g50C-2ej5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 THR A  19
LEU A  18
VAL A  15
PHE A  62
LEU A  92
 None
 1.28A 1wsvA-2ej5A:
undetectable		 1wsvA-2ej5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 THR A  19
LEU A  18
VAL A  15
PHE A  62
LEU A  92
 None
 1.32A 1wsvB-2ej5A:
undetectable		 1wsvB-2ej5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 11 ASP A  47
LYS A  97
THR A 203
GLY A 258
GLN A  14
 None
 1.40A 2hmaA-2ej5A:
undetectable		 2hmaA-2ej5A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 PHE A  29
PHE A  62
ALA A 101
LEU A  41
MET A  89
 None
 1.41A 2x2nD-2ej5A:
undetectable		 2x2nD-2ej5A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		3 / 3 TYR A 147
ASP A 119
HIS A  94
 None
 0.90A 3e23A-2ej5A:
undetectable		 3e23A-2ej5A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		3 / 3 ARG A 252
ASP A 240
GLN A  14
 None
 0.87A 3lcvB-2ej5A:
undetectable		 3lcvB-2ej5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 VAL A  99
VAL A  50
GLY A  45
ALA A  44
LEU A  41
 None
 1.08A 3pghD-2ej5A:
undetectable		 3pghD-2ej5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 VAL A  99
VAL A  50
GLY A  45
ALA A  44
LEU A  41
 None
 1.09A 4coxA-2ej5A:
undetectable		 4coxA-2ej5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 VAL A  99
VAL A  50
GLY A  45
ALA A  44
LEU A  41
 None
 1.08A 4coxB-2ej5A:
2.0		 4coxB-2ej5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 VAL A  99
VAL A  50
GLY A  45
ALA A  44
LEU A  41
 None
 1.08A 4coxD-2ej5A:
undetectable		 4coxD-2ej5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		4 / 7 TYR A  85
PHE A  29
ALA A 142
SER A 113
 None
 1.27A 4lv9A-2ej5A:
undetectable
4lv9B-2ej5A:
undetectable		 4lv9A-2ej5A:
20.16
4lv9B-2ej5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 10 ALA A 169
THR A 168
ALA A 172
VAL A 181
GLY A 105
 None
 1.01A 4qvyK-2ej5A:
undetectable
4qvyL-2ej5A:
undetectable		 4qvyK-2ej5A:
21.85
4qvyL-2ej5A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 10 ALA A 169
THR A 168
ALA A 172
VAL A 181
GLY A 105
 None
 1.01A 4qvyY-2ej5A:
undetectable
4qvyZ-2ej5A:
undetectable		 4qvyY-2ej5A:
21.85
4qvyZ-2ej5A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 8 ALA A 101
ALA A 102
ILE A  55
ALA A  61
LEU A  20
 None
 1.20A 4v1fA-2ej5A:
undetectable
4v1fB-2ej5A:
undetectable		 4v1fA-2ej5A:
19.57
4v1fB-2ej5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 8 GLY A 105
VAL A 103
ALA A 115
LEU A 114
GLY A  65
 None
 1.20A 4zauA-2ej5A:
undetectable		 4zauA-2ej5A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		4 / 7 VAL A 100
LEU A 198
SER A 199
GLU A 196
 None
 1.06A 4zphA-2ej5A:
undetectable
4zphB-2ej5A:
undetectable		 4zphA-2ej5A:
19.54
4zphB-2ej5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		5 / 12 PRO A 131
GLY A  65
ASN A  34
PHE A  29
LEU A 116
 None
 1.17A 5fa8A-2ej5A:
undetectable		 5fa8A-2ej5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		6 / 12 GLY A  65
ASN A  34
VAL A  37
THR A  38
ALA A 115
LEU A 114
 None
 1.46A 5kocA-2ej5A:
undetectable		 5kocA-2ej5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ej5 ENOYL-COA HYDRATASE
SUBUNIT II
(Geobacillus
kaustophilus) 		3 / 3 GLY A 111
VAL A  37
MET A  33
 None
 0.55A 5ycpA-2ej5A:
undetectable		 5ycpA-2ej5A:
14.01