SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ej9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 164
LEU A 160
MET A  56
LEU A  58
 None
 1.04A 1linA-2ej9A:
undetectable		 1linA-2ej9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A 163
LEU A  58
LEU A  62
 None
 0.67A 1mx1E-2ej9A:
undetectable		 1mx1E-2ej9A:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 7 TRP A  45
LYS A 106
ASN A 126
ALA A 139
 BTN  A1301 (-3.9A)
BTN  A1301 (-2.6A)
None
None
 0.32A 2ejgA-2ej9A:
26.0		 2ejgA-2ej9A:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 7 TRP A  45
LYS A 106
ASN A 126
ALA A 139
 BTN  A1301 (-3.9A)
BTN  A1301 (-2.6A)
None
None
 0.48A 2ejgB-2ej9A:
26.1		 2ejgB-2ej9A:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 107
ILE A  96
GLY A 109
SER A 141
LEU A 142
 None
None
BTN  A1301 (-3.4A)
None
None
 0.98A 3ai9X-2ej9A:
undetectable		 3ai9X-2ej9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 107
GLY A 124
ILE A 140
ASN A 128
VAL A 127
SER A 141
 None
BTN  A1301 (-3.6A)
None
None
None
None
 1.49A 3nk7A-2ej9A:
undetectable		 3nk7A-2ej9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 125
ILE A  96
LEU A  90
PHE A  92
ILE A  74
 None
 0.97A 3w67D-2ej9A:
undetectable		 3w67D-2ej9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 184
ILE A  74
ASN A  69
ILE A 180
 None
 1.04A 4jtpA-2ej9A:
undetectable		 4jtpA-2ej9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASN A 128
GLU A 154
TYR A  83
LEU A 142
 None
 1.03A 4twdB-2ej9A:
undetectable
4twdC-2ej9A:
undetectable		 4twdB-2ej9A:
21.34
4twdC-2ej9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 168
LEU A 167
LEU A  62
LEU A  58
 None
 0.79A 4wg0B-2ej9A:
undetectable
4wg0C-2ej9A:
undetectable		 4wg0B-2ej9A:
5.65
4wg0C-2ej9A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A  11
GLY A  37
ILE A 110
GLY A  39
 BTN  A1301 (-2.6A)
BTN  A1301 (-3.4A)
None
BTN  A1301 (-3.3A)
 0.85A 5alcL-2ej9A:
undetectable		 5alcL-2ej9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 118
LYS A  21
LYS A  17
 None
 0.70A 5dbyA-2ej9A:
undetectable		 5dbyA-2ej9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 107
ILE A  96
GLY A 109
LEU A 142
LEU A 150
 None
None
BTN  A1301 (-3.4A)
None
None
 1.15A 5nfjB-2ej9A:
undetectable		 5nfjB-2ej9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 107
ILE A  96
GLY A 109
LEU A 142
LEU A 150
 None
None
BTN  A1301 (-3.4A)
None
None
 1.12A 5nfjC-2ej9A:
undetectable		 5nfjC-2ej9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 107
ILE A  96
GLY A 109
SER A 141
LEU A 142
 None
None
BTN  A1301 (-3.4A)
None
None
 0.94A 5twjC-2ej9A:
undetectable		 5twjC-2ej9A:
19.42