SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 5 GLY A 138
LEU A 143
THR A 142
VAL A 181
 None
 0.97A 1ekjF-2ejaA:
undetectable
1ekjG-2ejaA:
undetectable		 1ekjF-2ejaA:
21.14
1ekjG-2ejaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 PHE A 237
PHE A 199
ILE A 264
TYR A 308
MET A  24
 None
 1.48A 1fm4A-2ejaA:
undetectable		 1fm4A-2ejaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ASP A  75
PRO A 318
ASP A 319
ALA A 317
ARG A  29
 None
 1.40A 1s14B-2ejaA:
undetectable		 1s14B-2ejaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.86A 1sdvB-2ejaA:
undetectable		 1sdvB-2ejaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 120
ALA A 137
 None
 1.04A 2b7zA-2ejaA:
undetectable		 2b7zA-2ejaA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 PHE A 237
HIS A 314
LEU A  77
ILE A  76
SER A 201
 None
 1.33A 2fj1A-2ejaA:
undetectable		 2fj1A-2ejaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 6 PHE A 238
ARG A 239
ASN A 205
LEU A  97
 None
 1.15A 2nyrA-2ejaA:
undetectable		 2nyrA-2ejaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.76A 2o4sB-2ejaA:
undetectable		 2o4sB-2ejaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.81A 2q5kB-2ejaA:
undetectable		 2q5kB-2ejaA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.83A 2r5qB-2ejaA:
undetectable		 2r5qB-2ejaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.82A 2r5qD-2ejaA:
undetectable		 2r5qD-2ejaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ASN A 205
ILE A  76
VAL A  87
PRO A  95
LEU A  97
 None
 1.44A 3a51B-2ejaA:
undetectable		 3a51B-2ejaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 120
ALA A 137
 None
 0.95A 3ekwB-2ejaA:
undetectable		 3ekwB-2ejaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.82A 3jw2B-2ejaA:
undetectable		 3jw2B-2ejaA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 5 VAL A  21
ILE A  71
PHE A 136
PHE A 199
 None
 0.70A 3owxB-2ejaA:
undetectable		 3owxB-2ejaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 PHE A  73
GLN A 188
PHE A  44
 None
 0.76A 3rv5A-2ejaA:
0.0		 3rv5A-2ejaA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 GLY A 192
ALA A 193
ASP A 194
ILE A 120
 None
 0.71A 3t3cA-2ejaA:
undetectable		 3t3cA-2ejaA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 SER A 257
LEU A 256
ILE A 302
LEU A  11
VAL A 195
 None
 1.10A 3w67A-2ejaA:
undetectable		 3w67A-2ejaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A  84
SER A  74
TYR A 116
ASN A 114
VAL A 117
 None
 1.29A 4ffwA-2ejaA:
undetectable		 4ffwA-2ejaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 VAL A 131
PRO A  20
GLN A  26
ILE A 134
 None
 1.08A 4iilA-2ejaA:
2.4		 4iilA-2ejaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 279
ASN A 278
GLY A 313
MET A  24
LEU A  23
 None
 1.23A 4p6xE-2ejaA:
undetectable		 4p6xE-2ejaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 8 ASN A 114
LEU A  83
LEU A  77
PHE A 136
GLY A 138
 None
 1.34A 4r3aA-2ejaA:
undetectable		 4r3aA-2ejaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 ILE A 235
GLN A 276
GLN A 197
ALA A 193
ILE A  71
 None
 1.40A 4rp9A-2ejaA:
0.0		 4rp9A-2ejaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ILE A 198
PHE A 237
LEU A 256
ALA A 253
ASP A 254
 None
 1.50A 5ajqB-2ejaA:
undetectable		 5ajqB-2ejaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ILE A 223
GLY A 274
LEU A 256
ALA A 248
ASP A 250
 None
 1.45A 5ajqB-2ejaA:
undetectable		 5ajqB-2ejaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 PHE A 136
ILE A  72
ASP A 194
 None
 0.71A 5cswA-2ejaA:
undetectable		 5cswA-2ejaA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 ARG A 307
PHE A 310
LEU A   7
 None
 0.86A 5veuA-2ejaA:
undetectable		 5veuA-2ejaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 GLN A 197
TRP A  22
VAL A 309
 None
 0.99A 6auuA-2ejaA:
undetectable		 6auuA-2ejaA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.75A 6dj1B-2ejaA:
undetectable		 6dj1B-2ejaA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ILE A 134
ILE A 120
 None
 0.77A 6dj2B-2ejaA:
undetectable		 6dj2B-2ejaA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2eja UROPORPHYRINOGEN
DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 VAL A 309
SER A  10
ALA A 255
PHE A 268
VAL A 304
 None
 1.44A 6drxA-2ejaA:
undetectable		 6drxA-2ejaA:
21.84