SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ejb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 11 LEU A  24
PHE A  29
VAL A 147
LEU A 173
LEU A 174
 None
 1.10A 1mx1A-2ejbA:
undetectable		 1mx1A-2ejbA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 PRO A  72
ASP A  32
LYS A   3
SER A  30
 None
 1.16A 1p7lC-2ejbA:
undetectable		 1p7lC-2ejbA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 PRO A  72
ASP A  32
LYS A   3
SER A  30
 None
 1.15A 1p7lD-2ejbA:
undetectable		 1p7lD-2ejbA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 121
VAL A  85
GLY A  84
LEU A 115
ALA A 114
 None
 0.97A 2egvB-2ejbA:
3.3		 2egvB-2ejbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 LEU A 121
VAL A  85
GLY A  84
LEU A 115
ALA A 114
 None
 0.85A 2v3kA-2ejbA:
undetectable		 2v3kA-2ejbA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.08A 4coxA-2ejbA:
undetectable		 4coxA-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.07A 4coxB-2ejbA:
undetectable		 4coxB-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.09A 4coxD-2ejbA:
undetectable		 4coxD-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 7 SER A  91
LYS A  40
ALA A  39
THR A   9
 None
 1.01A 4ikkA-2ejbA:
undetectable
4ikkB-2ejbA:
undetectable		 4ikkA-2ejbA:
20.86
4ikkB-2ejbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 PRO A  72
ASP A  32
LYS A   3
SER A  30
 None
 1.08A 4kttA-2ejbA:
undetectable		 4kttA-2ejbA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 PRO A  72
ASP A  32
LYS A   3
SER A  30
 None
 1.11A 4ndnA-2ejbA:
undetectable		 4ndnA-2ejbA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.08A 4otyA-2ejbA:
undetectable		 4otyA-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.09A 4otyB-2ejbA:
undetectable		 4otyB-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.02A 4rrwC-2ejbA:
undetectable		 4rrwC-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.00A 4rrwD-2ejbA:
undetectable		 4rrwD-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.02A 4rrzC-2ejbA:
undetectable		 4rrzC-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.00A 4rrzD-2ejbA:
undetectable		 4rrzD-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 ASP A  32
ARG A  78
PRO A  72
 None
 0.93A 4wanC-2ejbA:
undetectable		 4wanC-2ejbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 8 LEU A 173
GLY A 171
VAL A 169
ALA A 151
GLY A  17
 None
 1.10A 4zauA-2ejbA:
undetectable		 4zauA-2ejbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 8 PRO A  72
ASP A  32
LYS A   3
SER A  30
 None
 1.13A 5a1iA-2ejbA:
undetectable		 5a1iA-2ejbA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 177
VAL A  85
LEU A 123
VAL A 148
GLY A 145
 None
 1.49A 5i8fA-2ejbA:
undetectable		 5i8fA-2ejbA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 12 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.12A 5iktA-2ejbA:
undetectable		 5iktA-2ejbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		3 / 3 VAL A  23
ARG A 126
PRO A  89
 None
 0.71A 5koxA-2ejbA:
undetectable		 5koxA-2ejbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		5 / 10 ALA A  39
SER A  36
GLY A  13
ALA A  11
SER A  91
 None
 1.28A 5l66Y-2ejbA:
undetectable
5l66Z-2ejbA:
undetectable		 5l66Y-2ejbA:
22.22
5l66Z-2ejbA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE
(Aquifex
aeolicus) 		4 / 6 PRO A  89
GLY A  17
TYR A  16
LEU A  43
 None
 0.91A 5x80A-2ejbA:
undetectable
5x80B-2ejbA:
undetectable		 5x80A-2ejbA:
22.50
5x80B-2ejbA:
22.50