SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ejv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LEU A 169
GLU A 237
LEU A 193
LEU A 202
LEU A 212
 None
 1.17A 1ie4A-2ejvA:
undetectable
1ie4C-2ejvA:
undetectable		 1ie4A-2ejvA:
20.31
1ie4C-2ejvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LEU A 202
LEU A 212
LEU A 169
GLU A 237
LEU A 193
 None
 1.19A 1ie4A-2ejvA:
undetectable
1ie4C-2ejvA:
undetectable		 1ie4A-2ejvA:
20.31
1ie4C-2ejvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLY A 174
VAL A 335
ALA A 180
ALA A 181
ILE A 170
 NAD  A1350 (-3.2A)
None
None
None
None
 1.10A 1likA-2ejvA:
undetectable		 1likA-2ejvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 130
ASN A 131
TRP A 292
 None
 1.30A 1r15D-2ejvA:
2.1		 1r15D-2ejvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 130
ASN A 131
TRP A 292
 None
 1.28A 1r15F-2ejvA:
2.3		 1r15F-2ejvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 319
ALA A 122
LEU A   4
VAL A 125
 None
 1.20A 1sn5A-2ejvA:
undetectable		 1sn5A-2ejvA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 PRO A 199
LEU A 216
ARG A 201
GLY A 172
 None
None
NAD  A1350 (-4.0A)
NAD  A1350 (-3.7A)
 1.12A 2hs2B-2ejvA:
undetectable		 2hs2B-2ejvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 MET A 179
ALA A 180
GLY A 177
ILE A 176
 None
None
None
NAD  A1350 (-3.9A)
 0.63A 2zm9A-2ejvA:
undetectable		 2zm9A-2ejvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLY A 120
GLY A 114
GLY A  62
 None
 0.43A 3bogC-2ejvA:
undetectable		 3bogC-2ejvA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A 194
LEU A 216
LEU A 221
ILE A 170
 None
 0.89A 3gp0A-2ejvA:
undetectable		 3gp0A-2ejvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 GLY A  67
ILE A 146
PHE A 326
GLY A 120
PHE A 121
 None
 1.18A 3ko0A-2ejvA:
undetectable
3ko0C-2ejvA:
undetectable		 3ko0A-2ejvA:
13.37
3ko0C-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 GLY A 120
PHE A 121
GLY A  67
ILE A 146
PHE A 326
 None
 1.31A 3ko0F-2ejvA:
undetectable
3ko0G-2ejvA:
undetectable		 3ko0F-2ejvA:
13.37
3ko0G-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLY A 120
PHE A 121
GLY A  67
ILE A 146
PHE A 326
 None
 1.30A 3ko0L-2ejvA:
undetectable
3ko0N-2ejvA:
undetectable		 3ko0L-2ejvA:
13.37
3ko0N-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLY A 120
PHE A 121
ILE A  55
PHE A 326
 None
 0.94A 3ko0O-2ejvA:
undetectable
3ko0Q-2ejvA:
undetectable		 3ko0O-2ejvA:
13.37
3ko0Q-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLY A  67
ILE A 146
PHE A 326
GLY A 120
PHE A 121
 None
 1.20A 3ko0R-2ejvA:
undetectable
3ko0T-2ejvA:
undetectable		 3ko0R-2ejvA:
13.37
3ko0T-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 249
GLU A 275
LEU A 252
ILE A 281
 None
 0.77A 3s56B-2ejvA:
undetectable		 3s56B-2ejvA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A  60
GLY A 114
VAL A  30
VAL A  32
 None
 0.72A 3ufnB-2ejvA:
undetectable		 3ufnB-2ejvA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 TRP A 292
GLY A 298
TYR A 303
ASN A 135
 None
 0.89A 4fgkB-2ejvA:
3.7		 4fgkB-2ejvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 120
GLY A  62
GLY A 114
LEU A  87
SER A  89
VAL A 125
 None
 1.39A 4htfA-2ejvA:
7.1		 4htfA-2ejvA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLU A 148
SER A  89
ILE A 112
VAL A 115
 ZN  A 501 ( 4.0A)
None
None
None
 1.09A 4tvtA-2ejvA:
undetectable		 4tvtA-2ejvA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 319
ALA A 122
LEU A   4
VAL A 125
 None
 1.28A 5a6iA-2ejvA:
undetectable		 5a6iA-2ejvA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.50A 5eckA-2ejvA:
undetectable		 5eckA-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.50A 5eckD-2ejvA:
undetectable		 5eckD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.46A 5eclA-2ejvA:
undetectable		 5eclA-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.53A 5ecmD-2ejvA:
1.2		 5ecmD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.53A 5ecnD-2ejvA:
undetectable		 5ecnD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 153
VAL A 157
TYR A 158
VAL A 307
 None
 0.62A 5ecoD-2ejvA:
undetectable		 5ecoD-2ejvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 ALA A 189
VAL A 194
VAL A 157
GLY A 177
ALA A 173
LEU A 212
 None
 1.45A 5xxiA-2ejvA:
undetectable		 5xxiA-2ejvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 123
ASP A 340
PRO A 318
 None
 0.67A 6berA-2ejvA:
undetectable		 6berA-2ejvA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2ejv L-THREONINE
3-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
ASP A 196
VAL A 194
VAL A 168
ILE A 170
 None
NAD  A1350 (-2.4A)
None
None
None
 1.13A 6dgxB-2ejvA:
undetectable		 6dgxB-2ejvA:
15.69