SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ejw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A   7
GLY A  40
GLU A  72
LEU A  94
LEU A  64
 None
 1.31A 1cmcA-2ejwA:
undetectable
1cmcB-2ejwA:
undetectable		 1cmcA-2ejwA:
14.15
1cmcB-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLU A  72
LEU A  94
LEU A  64
ALA A   7
GLY A  40
 None
 1.29A 1cmcA-2ejwA:
undetectable
1cmcB-2ejwA:
undetectable		 1cmcA-2ejwA:
14.15
1cmcB-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 146
LEU A 264
LEU A 258
PRO A 259
 None
 1.34A 1hz4A-2ejwA:
undetectable		 1hz4A-2ejwA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 137
LEU A 145
ALA A 192
ALA A 240
VAL A 274
 None
 1.20A 1kt4A-2ejwA:
undetectable		 1kt4A-2ejwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 137
LEU A 145
ALA A 193
ALA A 240
VAL A 274
 None
 1.21A 1kt4A-2ejwA:
undetectable		 1kt4A-2ejwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A   7
GLY A  40
GLU A  72
LEU A  94
LEU A  64
 None
 1.28A 1mj2A-2ejwA:
undetectable
1mj2B-2ejwA:
undetectable		 1mj2A-2ejwA:
14.15
1mj2B-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A   7
GLY A  40
GLU A  72
LEU A  94
LEU A  64
 None
 1.25A 1mj2C-2ejwA:
undetectable
1mj2D-2ejwA:
undetectable		 1mj2C-2ejwA:
14.15
1mj2D-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A   7
GLY A  40
GLU A  72
LEU A  94
LEU A  64
 None
 1.25A 1mjoC-2ejwA:
undetectable
1mjoD-2ejwA:
undetectable		 1mjoC-2ejwA:
14.15
1mjoD-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLU A  72
LEU A  94
LEU A  64
ALA A   7
GLY A  40
 None
 1.33A 1mjqA-2ejwA:
undetectable
1mjqB-2ejwA:
undetectable		 1mjqA-2ejwA:
14.15
1mjqB-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLU A  72
LEU A  94
LEU A  64
ALA A   7
GLY A  40
 None
 1.29A 1mjqC-2ejwA:
undetectable
1mjqD-2ejwA:
undetectable		 1mjqC-2ejwA:
14.15
1mjqD-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLU A  72
LEU A  94
LEU A  64
ALA A   7
GLY A  40
 None
 1.31A 1mjqI-2ejwA:
undetectable
1mjqJ-2ejwA:
undetectable		 1mjqI-2ejwA:
14.15
1mjqJ-2ejwA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A  38
TYR A  19
LEU A 302
LEU A  29
PRO A  36
 None
 1.28A 1p33A-2ejwA:
8.9		 1p33A-2ejwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A  38
TYR A  19
LEU A 302
LEU A  29
PRO A  36
 None
 1.25A 1p33B-2ejwA:
undetectable		 1p33B-2ejwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A  38
TYR A  19
LEU A 302
LEU A  29
PRO A  36
 None
 1.28A 1p33C-2ejwA:
2.8		 1p33C-2ejwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLY A  15
GLY A  12
VAL A  71
LEU A 298
 None
 0.72A 2oa1B-2ejwA:
4.1		 2oa1B-2ejwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 301
LEU A  69
VAL A  84
 None
 0.52A 4jecB-2ejwA:
undetectable		 4jecB-2ejwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 199
SER A 132
VAL A 274
PHE A 283
 None
 1.00A 4wnvD-2ejwA:
undetectable		 4wnvD-2ejwA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 VAL A  41
LEU A  57
VAL A  43
 None
 0.51A 4wq4A-2ejwA:
undetectable		 4wq4A-2ejwA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 301
ARG A 304
TYR A 119
 None
 0.99A 5a7mA-2ejwA:
undetectable		 5a7mA-2ejwA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 301
ARG A 304
TYR A 119
 None
 0.99A 5a7mB-2ejwA:
undetectable		 5a7mB-2ejwA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ASP A 301
HIS A 120
GLY A 127
ALA A 126
 None
None
MG  A2003 ( 4.5A)
None
 1.03A 5hwaA-2ejwA:
undetectable		 5hwaA-2ejwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 GLY A 151
THR A 152
GLY A 325
LEU A 196
 NO3  A2602 (-3.2A)
NO3  A2602 (-4.4A)
None
None
 0.87A 5jlcA-2ejwA:
undetectable		 5jlcA-2ejwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 202
VAL A 204
LEU A 134
LEU A 279
 None
 0.93A 5tudD-2ejwA:
undetectable		 5tudD-2ejwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 134
LEU A 131
GLY A 207
ARG A 110
 None
 0.91A 6ce2A-2ejwA:
undetectable		 6ce2A-2ejwA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TRP A 106
ILE A 118
GLU A 115
 None
 0.84A 6hcxA-2ejwA:
undetectable		 6hcxA-2ejwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 2ejw HOMOSERINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LEU A  83
PRO A  80
LEU A 101
THR A  96
LEU A   8
 None
 1.48A 6hupD-2ejwA:
0.0
6hupE-2ejwA:
0.0		 6hupD-2ejwA:
14.05
6hupE-2ejwA:
12.05