SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ejx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  20
PHE A  26
ILE A  31
ASN A 115
LEU A 119
 None
 1.07A 1dhfA-2ejxA:
undetectable		 1dhfA-2ejxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  20
PHE A  26
ILE A  31
ASN A 115
LEU A 119
 None
 1.09A 1dhfB-2ejxA:
undetectable		 1dhfB-2ejxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A  85
ARG A  86
LEU A  93
LEU A  83
 None
 1.07A 2rlfA-2ejxA:
undetectable
2rlfD-2ejxA:
undetectable		 2rlfA-2ejxA:
16.67
2rlfD-2ejxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  20
PHE A  26
ILE A  31
ASN A 115
LEU A 119
 None
 1.06A 2w3bB-2ejxA:
undetectable		 2w3bB-2ejxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  20
PHE A  26
ILE A  31
ASN A 115
LEU A 119
 None
 1.09A 2w3mA-2ejxA:
undetectable		 2w3mA-2ejxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		4 / 7 ILE A  96
LEU A  97
GLY A  81
ARG A  71
 None
 0.77A 2wd9A-2ejxA:
undetectable		 2wd9A-2ejxA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  96
LEU A  97
GLY A  81
ARG A  71
 None
 0.71A 2wd9B-2ejxA:
undetectable		 2wd9B-2ejxA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		5 / 10 TYR A  57
PHE A  52
GLY A 108
ALA A 105
TYR A  74
 None
 1.33A 2xtkB-2ejxA:
undetectable		 2xtkB-2ejxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		4 / 8 VAL A   4
TYR A  84
VAL A 112
ILE A  95
 None
 1.10A 4aftD-2ejxA:
undetectable
4aftE-2ejxA:
undetectable		 4aftD-2ejxA:
18.55
4aftE-2ejxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  20
PHE A  26
ILE A  31
ASN A 115
LEU A 119
 None
 1.08A 4kebB-2ejxA:
undetectable		 4kebB-2ejxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		4 / 5 ILE A  82
ILE A  96
ARG A  86
GLU A  69
 None
 1.25A 4zzcE-2ejxA:
undetectable		 4zzcE-2ejxA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ejx STK_08120
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A   9
LEU A 116
ILE A  85
 None
 0.79A 5kc4A-2ejxA:
undetectable		 5kc4A-2ejxA:
26.04