SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ek8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 11 LEU A 300
HIS A 363
LEU A 334
LEU A 311
VAL A 247
 None
 1.21A 1ee2A-2ek8A:
undetectable		 1ee2A-2ek8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 11 LEU A 300
HIS A 363
LEU A 334
LEU A 311
VAL A 247
 None
 1.22A 1ee2B-2ek8A:
3.5		 1ee2B-2ek8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 7 GLY A 244
SER A 227
HIS A 229
ALA A  40
 None
 0.95A 1gxsA-2ek8A:
4.3
1gxsB-2ek8A:
undetectable		 1gxsA-2ek8A:
22.33
1gxsB-2ek8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 ILE A 207
GLY A 270
VAL A  41
GLU A  45
PRO A  59
 None
 1.17A 1sg9C-2ek8A:
undetectable		 1sg9C-2ek8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 4 LEU A 360
SER A 279
ASP A 241
ASP A 375
 None
None
ZN  A1002 ( 4.7A)
None
 1.19A 2br4B-2ek8A:
undetectable		 2br4B-2ek8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 GLY A 103
GLY A 101
ASP A 107
ALA A 106
THR A 105
 None
 1.05A 2gluA-2ek8A:
2.2		 2gluA-2ek8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.83A 2nmzA-2ek8A:
undetectable		 2nmzA-2ek8A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.80A 2nnkA-2ek8A:
undetectable		 2nnkA-2ek8A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 VAL A 323
LEU A 251
LEU A 300
PHE A 361
LEU A 311
 None
 1.09A 2oipC-2ek8A:
undetectable		 2oipC-2ek8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 10 ALA A 330
THR A  13
LEU A 251
MET A 255
VAL A 254
 None
ZN  A1004 (-3.2A)
None
None
None
 1.17A 2wuzB-2ek8A:
undetectable		 2wuzB-2ek8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 GLY A 226
ILE A 207
THR A 248
ASN A 205
PHE A  60
 None
 1.44A 3a25A-2ek8A:
undetectable		 3a25A-2ek8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 SER A  88
ALA A  84
GLY A  82
GLY A 168
VAL A 193
 None
 0.99A 3f8wA-2ek8A:
6.5		 3f8wA-2ek8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 SER A  88
ALA A  84
GLY A  82
GLY A 168
VAL A 193
 None
 1.02A 3f8wC-2ek8A:
6.6		 3f8wC-2ek8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 VAL A 323
LEU A 251
LEU A 300
PHE A 361
LEU A 311
 None
 1.10A 3hj3C-2ek8A:
undetectable		 3hj3C-2ek8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 VAL A 323
LEU A 251
LEU A 300
PHE A 361
LEU A 311
 None
 1.09A 3hj3D-2ek8A:
undetectable		 3hj3D-2ek8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.78A 3k4vA-2ek8A:
undetectable		 3k4vA-2ek8A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.83A 3k4vD-2ek8A:
undetectable		 3k4vD-2ek8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.69A 3ndtA-2ek8A:
undetectable		 3ndtA-2ek8A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.83A 3nduD-2ek8A:
undetectable		 3nduD-2ek8A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ASP A 241
GLU A 367
SER A 279
 ZN  A1002 ( 4.7A)
None
None
 0.81A 3p2kA-2ek8A:
undetectable		 3p2kA-2ek8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 5 GLU A 383
LEU A 385
HIS A 363
GLY A 304
 ZN  A1006 (-2.1A)
None
None
None
 1.13A 3pp1A-2ek8A:
undetectable		 3pp1A-2ek8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.76A 3pwrA-2ek8A:
undetectable		 3pwrA-2ek8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		3 / 3 ARG A  42
VAL A 245
THR A 268
 None
 0.79A 3tl9A-2ek8A:
undetectable		 3tl9A-2ek8A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 HIS A 348
ILE A 362
LEU A 300
GLY A 244
ALA A 389
 None
 1.23A 4fqsA-2ek8A:
undetectable		 4fqsA-2ek8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 HIS A 348
ILE A 362
LEU A 300
GLY A 244
ALA A 389
 None
 1.25A 4fqsB-2ek8A:
undetectable		 4fqsB-2ek8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 SER A 243
ASN A 239
LEU A 360
ILE A 362
GLN A 299
 None
 1.39A 4kukA-2ek8A:
undetectable		 4kukA-2ek8A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 7 LEU A 249
VAL A 245
LYS A  49
TYR A  53
 None
 0.95A 4lb2A-2ek8A:
undetectable		 4lb2A-2ek8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 6 ASP A 240
ASN A 239
ALA A 238
ASP A 230
 ZN  A1001 ( 2.4A)
None
None
None
 1.09A 4mdaA-2ek8A:
undetectable		 4mdaA-2ek8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 11 HIS A 228
ASP A 240
GLU A 272
GLU A 273
HIS A 371
 ZN  A1002 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 ( 3.9A)
ZN  A1001 (-2.0A)
ZN  A1001 (-3.3A)
 0.31A 4pqaA-2ek8A:
23.4		 4pqaA-2ek8A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 7 GLY A 304
LEU A 385
LEU A 334
GLY A 244
LEU A 300
 None
 1.14A 5vkqA-2ek8A:
undetectable
5vkqB-2ek8A:
undetectable		 5vkqA-2ek8A:
13.68
5vkqB-2ek8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 8 GLY A 304
LEU A 385
LEU A 334
GLY A 244
LEU A 300
 None
 1.14A 5vkqB-2ek8A:
undetectable
5vkqC-2ek8A:
undetectable		 5vkqB-2ek8A:
13.68
5vkqC-2ek8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 7 ASN A 274
ASP A 230
ASP A 240
GLY A 237
 None
None
ZN  A1001 ( 2.4A)
None
 1.11A 5x7pA-2ek8A:
undetectable		 5x7pA-2ek8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		5 / 12 VAL A 254
THR A  13
VAL A 396
GLY A 393
PHE A 266
 None
ZN  A1004 (-3.2A)
None
None
None
 1.18A 6a94B-2ek8A:
undetectable		 6a94B-2ek8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 5 VAL A  41
PHE A 298
MET A 297
GLY A 296
 None
 1.31A 6hd4A-2ek8A:
undetectable		 6hd4A-2ek8A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2ek8 AMINOPEPTIDASE
(Aneurinibacillus
sp.
AM-1) 		4 / 5 VAL A  57
PHE A 298
MET A 297
GLY A 296
 None
 1.39A 6hd4A-2ek8A:
undetectable		 6hd4A-2ek8A:
12.61