SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ekc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 10 PHE A 176
PRO A 156
VAL A 177
VAL A 198
ILE A 127
 None
 1.43A 13gsA-2ekcA:
undetectable		 13gsA-2ekcA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 9 PHE A 176
PRO A 156
VAL A 177
VAL A 198
ILE A 127
 None
 1.43A 13gsB-2ekcA:
0.0		 13gsB-2ekcA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 11 PRO A 152
VAL A 232
VAL A 177
GLY A 212
LEU A  98
 None
 1.10A 1fkpA-2ekcA:
undetectable		 1fkpA-2ekcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		3 / 3 ILE A 246
LEU A 249
VAL A 253
 None
 0.46A 1mz9B-2ekcA:
undetectable		 1mz9B-2ekcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		4 / 7 TYR A  22
GLY A  51
TYR A 102
ASP A  29
 None
 1.08A 2g72B-2ekcA:
undetectable		 2g72B-2ekcA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 11 VAL A 215
LEU A 252
VAL A 253
SER A 235
ALA A  18
 None
 1.14A 2zbzA-2ekcA:
undetectable		 2zbzA-2ekcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		4 / 8 LEU A  23
SER A  21
VAL A 253
ALA A 236
 None
 0.84A 3ax9A-2ekcA:
undetectable		 3ax9A-2ekcA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 10 PHE A  52
ILE A  76
ALA A  67
ASP A  80
VAL A  81
 None
 1.27A 3ay0A-2ekcA:
undetectable		 3ay0A-2ekcA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		4 / 6 MET A 173
VAL A 151
ILE A  47
ILE A 127
 None
 0.92A 3gcsA-2ekcA:
undetectable		 3gcsA-2ekcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 12 ILE A 109
GLU A  79
PHE A  78
ILE A 123
LEU A  99
 None
 1.19A 3ia4D-2ekcA:
undetectable		 3ia4D-2ekcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		4 / 7 ALA A 228
ASP A 229
VAL A 232
ILE A 166
 None
 0.92A 4eyrA-2ekcA:
undetectable		 4eyrA-2ekcA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		4 / 7 VAL A 210
ALA A 228
PHE A 227
TYR A 191
 None
 1.10A 4lb2A-2ekcA:
undetectable		 4lb2A-2ekcA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 12 MET A 173
THR A 174
GLY A 230
ALA A  18
ASP A  46
 None
 1.18A 5kvaA-2ekcA:
undetectable		 5kvaA-2ekcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Aquifex
aeolicus) 		5 / 12 GLY A 259
GLY A 230
GLY A 225
ALA A  18
ASP A  46
 None
 1.25A 5x7fA-2ekcA:
undetectable		 5x7fA-2ekcA:
23.16