SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ekd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		4 / 8 SER A 175
ILE A  33
PHE A   6
VAL A 199
 None
 1.09A 1kb9A-2ekdA:
undetectable
1kb9C-2ekdA:
undetectable
1kb9D-2ekdA:
undetectable
1kb9E-2ekdA:
undetectable		 1kb9A-2ekdA:
19.77
1kb9C-2ekdA:
18.91
1kb9D-2ekdA:
20.78
1kb9E-2ekdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		5 / 9 LEU A  57
VAL A  34
ILE A  33
ILE A 184
PHE A 152
 None
 1.05A 1q6iA-2ekdA:
undetectable		 1q6iA-2ekdA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		5 / 11 PHE A 150
PHE A 152
PHE A  10
LEU A  29
PHE A   6
 None
 1.17A 3t3rA-2ekdA:
undetectable		 3t3rA-2ekdA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		5 / 8 ILE A 113
ILE A  33
PHE A   6
VAL A  16
SER A 189
 None
 1.04A 4ac9C-2ekdA:
undetectable		 4ac9C-2ekdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		4 / 8 ILE A  33
PHE A   6
VAL A  16
SER A 189
 None
 0.93A 4acbB-2ekdA:
undetectable
4acbC-2ekdA:
2.4		 4acbB-2ekdA:
20.00
4acbC-2ekdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		4 / 8 TYR A 100
VAL A  43
VAL A  70
ILE A  85
 None
 1.16A 4aftD-2ekdA:
undetectable
4aftE-2ekdA:
undetectable		 4aftD-2ekdA:
22.88
4aftE-2ekdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		5 / 11 LEU A  57
VAL A  34
ILE A  33
ILE A 184
PHE A 152
 None
 1.15A 5d75A-2ekdA:
undetectable		 5d75A-2ekdA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		4 / 8 LEU A 177
VAL A  18
VAL A  16
ILE A  33
 None
 0.76A 5y9mA-2ekdA:
undetectable		 5y9mA-2ekdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2ekd HYPOTHETICAL PROTEIN
PH0250
(Pyrococcus
horikoshii) 		5 / 9 LEU A 177
VAL A  18
VAL A  16
ILE A 113
ILE A  33
 None
 0.92A 5yf9X-2ekdA:
undetectable		 5yf9X-2ekdA:
19.69