SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ekl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A  79
VAL A  58
ILE A  71
THR A  84
ILE A  82
 None
 0.89A 1c6yA-2eklA:
undetectable		 1c6yA-2eklA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 THR A 299
LEU A 303
LEU A 310
 None
 0.63A 1mz9C-2eklA:
undetectable		 1mz9C-2eklA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 ILE A 145
ILE A 214
ILE A 227
MET A 113
 None
 0.82A 1zgyA-2eklA:
undetectable		 1zgyA-2eklA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A   9
LEU A  41
VAL A  62
VAL A  52
 None
 0.97A 2bdmA-2eklA:
undetectable		 2bdmA-2eklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 ALA A 253
GLY A 249
LYS A 247
HIS A 275
 None
 1.49A 2ylgA-2eklA:
undetectable		 2ylgA-2eklA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A  79
ILE A  63
ALA A  73
LEU A 303
 None
 0.66A 3kk6B-2eklA:
undetectable		 3kk6B-2eklA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  10
ALA A   8
GLN A  28
ILE A  17
LEU A 303
 None
 0.91A 3oapA-2eklA:
undetectable		 3oapA-2eklA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLN A  28
ALA A   8
LEU A   9
ILE A 313
GLY A  26
 None
 1.05A 3ozwB-2eklA:
3.2		 3ozwB-2eklA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		6 / 11 VAL A  51
ALA A  73
LEU A 303
VAL A 295
ASP A  15
GLU A  16
 None
 1.45A 4iaaA-2eklA:
undetectable		 4iaaA-2eklA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 4 LYS A 274
LEU A 272
GLU A 271
LEU A 243
 None
 1.11A 4k4yE-2eklA:
undetectable		 4k4yE-2eklA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 LEU A  79
VAL A  58
ILE A  71
THR A  84
ILE A  82
 None
 0.96A 4njuB-2eklA:
undetectable		 4njuB-2eklA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 LEU A  79
VAL A  58
ILE A  71
THR A  84
ILE A  82
 None
 0.95A 4njuD-2eklA:
undetectable		 4njuD-2eklA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 MET A 298
MET A 307
TYR A  96
 None
 1.21A 4p6xI-2eklA:
undetectable		 4p6xI-2eklA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 THR A 299
VAL A 295
THR A  11
ILE A  82
ASN A  81
 None
 1.36A 4s0vA-2eklA:
5.3		 4s0vA-2eklA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A  80
GLU A  85
SER A 101
 None
None
NAD  A1300 (-3.1A)
 0.75A 5bw4B-2eklA:
undetectable		 5bw4B-2eklA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 GLY A 239
GLU A 271
HIS A 275
ASP A 244
 None
 1.26A 5c0oH-2eklA:
7.2		 5c0oH-2eklA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 158
GLY A  76
GLY A  78
HIS A 203
THR A 155
 None
 1.07A 5eqbA-2eklA:
undetectable		 5eqbA-2eklA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  44
GLU A  85
THR A  84
ALA A  87
LEU A  69
 None
 1.15A 5ienA-2eklA:
undetectable		 5ienA-2eklA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 ALA A 253
GLY A 249
LYS A 247
HIS A 275
 None
 1.48A 5jliA-2eklA:
undetectable		 5jliA-2eklA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 THR A 256
GLY A 285
ILE A  77
ALA A 291
ALA A 105
 None
NAD  A1300 (-3.2A)
NAD  A1300 (-4.8A)
None
NAD  A1300 ( 3.8A)
 1.02A 5kvaA-2eklA:
4.1		 5kvaA-2eklA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 THR A 256
GLY A 285
ILE A  77
ALA A 291
ALA A 105
 None
NAD  A1300 (-3.2A)
NAD  A1300 (-4.8A)
None
NAD  A1300 ( 3.8A)
 1.00A 5kvaB-2eklA:
4.1		 5kvaB-2eklA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LYS A 265
GLU A 267
GLU A 269
LEU A 270
LEU A 273
 None
 1.15A 5nwvA-2eklA:
undetectable		 5nwvA-2eklA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A  51
ILE A  49
VAL A  29
ALA A   8
 None
 0.72A 5ospA-2eklA:
undetectable		 5ospA-2eklA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  95
ILE A  71
TYR A  31
ALA A 296
LEU A  18
 None
 1.19A 6ajiA-2eklA:
undetectable		 6ajiA-2eklA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  14
ALA A  73
VAL A  95
ARG A  74
 None
 0.83A 6hu9a-2eklA:
undetectable
6hu9e-2eklA:
undetectable		 6hu9a-2eklA:
19.93
6hu9e-2eklA:
19.10