SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ekm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  96
ILE A  88
GLY A  46
THR A  35
ILE A 100
 None
 0.87A 1c6yB-2ekmA:
undetectable		 1c6yB-2ekmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  46
GLY A  62
ALA A  37
GLN A  72
LEU A  70
 None
 1.24A 1i9gA-2ekmA:
undetectable		 1i9gA-2ekmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  68
ILE A  47
ALA A  71
LEU A  67
LEU A  43
 None
 1.11A 1xzxX-2ekmA:
undetectable		 1xzxX-2ekmA:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		5 / 10 ASN A  17
ILE A  94
ALA A 114
ASN A 115
TYR A 160
 None
 0.29A 2gl0A-2ekmA:
27.6
2gl0B-2ekmA:
27.7		 2gl0A-2ekmA:
66.47
2gl0B-2ekmA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		6 / 11 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.34A 2gl0B-2ekmA:
27.7
2gl0C-2ekmA:
27.8		 2gl0B-2ekmA:
66.47
2gl0C-2ekmA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		6 / 12 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.35A 2gl0A-2ekmA:
27.6
2gl0C-2ekmA:
27.8		 2gl0A-2ekmA:
66.47
2gl0C-2ekmA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		6 / 12 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.37A 2gl0D-2ekmA:
27.7
2gl0E-2ekmA:
27.4		 2gl0D-2ekmA:
66.47
2gl0E-2ekmA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		6 / 11 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.33A 2gl0E-2ekmA:
27.4
2gl0F-2ekmA:
27.9		 2gl0E-2ekmA:
66.47
2gl0F-2ekmA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		6 / 11 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.35A 2gl0D-2ekmA:
27.7
2gl0F-2ekmA:
27.9		 2gl0D-2ekmA:
66.47
2gl0F-2ekmA:
66.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  86
ALA A 112
ILE A 100
PHE A  84
 None
 0.73A 2w9sE-2ekmA:
undetectable		 2w9sE-2ekmA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		4 / 4 ILE A  47
GLN A  72
ILE A  88
LEU A  76
 None
 1.21A 3dzyD-2ekmA:
undetectable		 3dzyD-2ekmA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  68
ILE A  47
ALA A  71
LEU A  67
LEU A  43
 None
 1.08A 3gwsX-2ekmA:
undetectable		 3gwsX-2ekmA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A  87
THR A  74
VAL A 119
VAL A  10
 None
 0.92A 4em2A-2ekmA:
undetectable		 4em2A-2ekmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		5 / 9 ALA A  80
ILE A  20
GLY A  21
ILE A 131
VAL A 121
 None
 0.99A 4nptA-2ekmA:
undetectable		 4nptA-2ekmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		4 / 4 GLY A  21
LEU A  36
PHE A  45
ILE A  47
 None
 0.99A 4xv2A-2ekmA:
undetectable		 4xv2A-2ekmA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		4 / 5 GLY A 129
ARG A 128
GLY A 127
GLU A 123
 None
 1.24A 4z2eB-2ekmA:
undetectable
4z2eC-2ekmA:
undetectable		 4z2eB-2ekmA:
19.17
4z2eC-2ekmA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2ekm HYPOTHETICAL PROTEIN
ST1511
(Sulfurisphaera
tokodaii) 		3 / 3 TRP A  60
ILE A  47
ASP A  61
 None
 0.87A 6i0y7-2ekmA:
undetectable		 6i0y7-2ekmA:
13.79