SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ekn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C
(Pyrococcus
horikoshii) 		4 / 8 PHE A  88
ALA A  56
ILE A  60
ASN A  53
 None
 1.17A 1pnlA-2eknA:
undetectable
1pnlB-2eknA:
undetectable		 1pnlA-2eknA:
24.19
1pnlB-2eknA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C
(Pyrococcus
horikoshii) 		5 / 12 ILE A  63
GLY A  62
ILE A 124
ALA A  65
VAL A  84
 None
 0.99A 3fpjA-2eknA:
undetectable		 3fpjA-2eknA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C
(Pyrococcus
horikoshii) 		4 / 6 GLY A  62
ILE A  60
GLN A  59
VAL A  84
 None
 0.94A 4d39B-2eknA:
undetectable		 4d39B-2eknA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C
(Pyrococcus
horikoshii) 		4 / 6 GLY A  62
ILE A  60
GLN A  59
VAL A  84
 None
 0.91A 4kcnA-2eknA:
undetectable		 4kcnA-2eknA:
16.86