SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2elc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 LEU A  74
ILE A  76
LEU A 205
VAL A 215
GLY A 191
None
1.13A 1e7aB-2elcA:
undetectable
1e7aB-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 4 ARG A  57
ALA A  58
ALA A  18
GLU A  15
None
1.12A 1e7bA-2elcA:
undetectable
1e7bA-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 5 ARG A  57
ALA A  58
ALA A  18
GLU A  15
None
1.14A 1e7cA-2elcA:
undetectable
1e7cA-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
6 / 12 ALA A 116
GLY A  85
GLY A 258
GLY A 259
LEU A 252
LEU A 255
None
GOL  A2010 ( 4.5A)
None
None
None
None
1.23A 1eizA-2elcA:
2.2
1eizA-2elcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
6 / 12 ALA A 116
GLY A  85
GLY A 258
GLY A 259
LEU A 252
LEU A 255
None
GOL  A2010 ( 4.5A)
None
None
None
None
1.21A 1ej0A-2elcA:
2.1
1ej0A-2elcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 GLY A 108
VAL A 127
LEU A 129
LEU A 327
PHE A 145
GOL  A2003 ( 3.8A)
None
None
None
None
1.21A 1mx1E-2elcA:
undetectable
1mx1E-2elcA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 VAL A 214
LEU A 176
ALA A 204
LEU A 205
None
0.88A 1pthA-2elcA:
undetectable
1pthA-2elcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 VAL A 214
LEU A 176
ALA A 204
LEU A 205
None
0.88A 1pthB-2elcA:
undetectable
1pthB-2elcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 10 VAL A 215
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.83A 1pxxA-2elcA:
undetectable
1pxxA-2elcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.06A 1pxxC-2elcA:
undetectable
1pxxC-2elcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
6 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.89A 1pxxC-2elcA:
undetectable
1pxxC-2elcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 10 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
None
0.83A 1pxxD-2elcA:
undetectable
1pxxD-2elcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 10 THR A 297
ALA A 294
ALA A 187
VAL A 102
GLY A 288
None
0.97A 2f16K-2elcA:
undetectable
2f16L-2elcA:
undetectable
2f16K-2elcA:
20.12
2f16L-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 10 THR A 297
ALA A 294
ALA A 187
VAL A 102
GLY A 288
None
0.96A 2f16Y-2elcA:
undetectable
2f16Z-2elcA:
undetectable
2f16Y-2elcA:
20.12
2f16Z-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 6 PHE A 153
TYR A 323
ARG A 135
GLY A 137
None
1.35A 2i30A-2elcA:
undetectable
2i30A-2elcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 SER A 118
LEU A 319
PHE A 147
VAL A 104
ALA A 103
None
1.05A 2kceA-2elcA:
undetectable
2kceA-2elcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 5 LEU A 327
VAL A 283
LEU A  89
ARG A 269
None
0.98A 2oiqA-2elcA:
undetectable
2oiqA-2elcA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 ALA A 119
GLY A 117
ASP A 120
LEU A 129
None
0.80A 2uyqA-2elcA:
undetectable
2uyqA-2elcA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 8 ALA A 282
ALA A 284
GLY A 290
ALA A  93
None
0.92A 2vh3B-2elcA:
undetectable
2vh3B-2elcA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 GLY A  78
ILE A  76
LEU A 179
VAL A 189
LEU A 198
GOL  A2003 ( 4.8A)
None
None
None
None
0.90A 2yqzA-2elcA:
2.3
2yqzA-2elcA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 GLY A  78
ILE A  76
LEU A 179
VAL A 189
LEU A 198
GOL  A2003 ( 4.8A)
None
None
None
None
0.89A 2yqzB-2elcA:
2.4
2yqzB-2elcA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 ALA A 187
PRO A 182
ALA A 183
ILE A  76
ALA A  94
None
0.99A 3jb1A-2elcA:
undetectable
3jb1A-2elcA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 LEU A  89
ASN A 263
GLY A 257
LEU A 270
GLU A 222
None
None
None
None
GOL  A2010 ( 3.9A)
1.24A 3medA-2elcA:
undetectable
3medB-2elcA:
undetectable
3medA-2elcA:
21.16
3medB-2elcA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 11 VAL A 215
TYR A 238
GLY A 290
ALA A 289
LEU A 285
None
1.00A 3n8yA-2elcA:
undetectable
3n8yA-2elcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.01A 3n8zB-2elcA:
undetectable
3n8zB-2elcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.01A 3n8zB-2elcA:
undetectable
3n8zB-2elcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
None
0.81A 3n8zB-2elcA:
undetectable
3n8zB-2elcA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 ASN A 109
ALA A 150
ARG A 158
ALA A 161
None
0.71A 3twpA-2elcA:
46.4
3twpA-2elcA:
39.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 ASN A 109
ALA A 150
ARG A 158
ALA A 161
None
0.84A 3twpB-2elcA:
46.2
3twpB-2elcA:
39.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 ASN A 109
ALA A 150
ARG A 158
ALA A 161
None
0.94A 3twpC-2elcA:
46.1
3twpC-2elcA:
39.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 ASN A 263
GLY A 258
GLY A 257
SER A 114
GLY A 259
None
1.21A 3ztvA-2elcA:
undetectable
3ztvA-2elcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 6 GLY A  28
ARG A  34
GLU A  20
ARG A  23
None
1.45A 4bqfA-2elcA:
undetectable
4bqfA-2elcA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.06A 4coxA-2elcA:
undetectable
4coxA-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.17A 4coxB-2elcA:
undetectable
4coxB-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.06A 4coxB-2elcA:
undetectable
4coxB-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.06A 4coxD-2elcA:
undetectable
4coxD-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 8 ASN A 181
GLY A 184
ALA A 185
ASP A 186
None
GOL  A2004 ( 4.4A)
None
None
0.82A 4eyrB-2elcA:
undetectable
4eyrB-2elcA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 5 LEU A  89
LEU A 285
LEU A 270
ASN A 228
None
0.92A 4n09B-2elcA:
6.1
4n09B-2elcA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.05A 4otyA-2elcA:
undetectable
4otyA-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.07A 4otyB-2elcA:
undetectable
4otyB-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 ALA A 294
ALA A 293
GLY A 101
GLY A 100
ALA A  97
None
1.07A 4qvmK-2elcA:
undetectable
4qvmL-2elcA:
undetectable
4qvmK-2elcA:
20.12
4qvmL-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 THR A 297
ALA A 294
ALA A 187
GLY A 288
ALA A  97
None
1.20A 4qvnK-2elcA:
undetectable
4qvnL-2elcA:
undetectable
4qvnK-2elcA:
20.12
4qvnL-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 THR A 297
ALA A 294
ALA A 187
GLY A 288
ALA A  97
None
1.20A 4qvnY-2elcA:
undetectable
4qvnZ-2elcA:
undetectable
4qvnY-2elcA:
20.12
4qvnZ-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 10 ALA A 294
ALA A 293
GLY A 101
GLY A 100
ALA A  97
None
1.07A 4qw3K-2elcA:
undetectable
4qw3L-2elcA:
undetectable
4qw3K-2elcA:
20.12
4qw3L-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 10 ALA A 294
ALA A 293
GLY A 101
GLY A 100
ALA A  97
None
1.07A 4qw3Y-2elcA:
undetectable
4qw3Z-2elcA:
undetectable
4qw3Y-2elcA:
20.12
4qw3Z-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 THR A 297
ALA A 294
ALA A 187
GLY A 303
GLY A 288
None
1.07A 4qwuY-2elcA:
undetectable
4qwuZ-2elcA:
undetectable
4qwuY-2elcA:
20.12
4qwuZ-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.05A 4rrxA-2elcA:
undetectable
4rrxA-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.94A 4rrxA-2elcA:
undetectable
4rrxA-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
None
0.87A 4rrxA-2elcA:
undetectable
4rrxA-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.05A 4rrxB-2elcA:
undetectable
4rrxB-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.93A 4rrxB-2elcA:
undetectable
4rrxB-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
None
0.86A 4rrxB-2elcA:
undetectable
4rrxB-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 8 ALA A  97
ALA A 293
ALA A 289
ALA A 287
None
0.78A 4twdF-2elcA:
undetectable
4twdG-2elcA:
undetectable
4twdH-2elcA:
undetectable
4twdI-2elcA:
undetectable
4twdJ-2elcA:
undetectable
4twdF-2elcA:
21.98
4twdG-2elcA:
21.98
4twdH-2elcA:
21.98
4twdI-2elcA:
21.98
4twdJ-2elcA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 LEU A 271
ALA A 267
ALA A  94
VAL A  96
ALA A 316
None
1.07A 4x1iB-2elcA:
undetectable
4x1iB-2elcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 11 PHE A 291
ALA A 284
VAL A 283
GLY A 100
GLY A 288
None
1.23A 4xnxA-2elcA:
undetectable
4xnxA-2elcA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 7 LEU A 311
ALA A 284
ALA A 286
LEU A 270
ALA A 280
None
1.21A 4z90F-2elcA:
undetectable
4z90G-2elcA:
undetectable
4z90H-2elcA:
undetectable
4z90J-2elcA:
undetectable
4z90F-2elcA:
22.47
4z90G-2elcA:
22.47
4z90H-2elcA:
22.47
4z90J-2elcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 5 LEU A  89
ALA A 286
LEU A  92
VAL A 304
None
1.21A 5cr1A-2elcA:
undetectable
5cr1A-2elcA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 PRO A 242
LEU A 240
VAL A 189
LEU A 300
TYR A 238
None
1.33A 5cymA-2elcA:
undetectable
5cymA-2elcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 PRO A 242
LEU A 240
VAL A 189
LEU A 300
TYR A 238
None
1.33A 5cyqA-2elcA:
undetectable
5cyqA-2elcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 ALA A 294
ALA A 293
GLY A 101
GLY A 100
ALA A  97
None
1.06A 5d0xK-2elcA:
undetectable
5d0xL-2elcA:
undetectable
5d0xK-2elcA:
20.12
5d0xL-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 9 ALA A 294
ALA A 293
GLY A 101
GLY A 100
ALA A  97
None
1.06A 5d0xY-2elcA:
undetectable
5d0xZ-2elcA:
undetectable
5d0xY-2elcA:
20.12
5d0xZ-2elcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 8 VAL A 215
LEU A  74
GLY A 290
ALA A 289
None
0.73A 5f1aA-2elcA:
undetectable
5f1aA-2elcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 7 VAL A 215
LEU A  74
GLY A 290
ALA A 289
None
0.69A 5f1aB-2elcA:
undetectable
5f1aB-2elcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.01A 5ikqA-2elcA:
undetectable
5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.94A 5ikqA-2elcA:
undetectable
5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
None
0.81A 5ikqA-2elcA:
undetectable
5ikqA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
0.98A 5ikqB-2elcA:
undetectable
5ikqB-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.92A 5ikqB-2elcA:
undetectable
5ikqB-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
None
0.81A 5ikqB-2elcA:
undetectable
5ikqB-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
None
1.06A 5iktA-2elcA:
undetectable
5iktA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
6 / 12 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
0.90A 5iktA-2elcA:
undetectable
5iktA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 VAL A 245
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.17A 5iktB-2elcA:
undetectable
5iktB-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 6 HIS A 107
VAL A  77
LEU A 179
THR A 180
GOL  A2003 ( 3.0A)
None
None
None
1.26A 5ogjA-2elcA:
undetectable
5ogjA-2elcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 6 HIS A 107
VAL A  77
LEU A 179
THR A 180
GOL  A2003 ( 3.0A)
None
None
None
1.24A 5ogjB-2elcA:
undetectable
5ogjB-2elcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 5 HIS A 107
VAL A  77
LEU A 179
THR A 180
GOL  A2003 ( 3.0A)
None
None
None
1.25A 5ohhA-2elcA:
undetectable
5ohhA-2elcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 6 HIS A 107
VAL A  77
LEU A 179
THR A 180
GOL  A2003 ( 3.0A)
None
None
None
1.26A 5ohhB-2elcA:
undetectable
5ohhB-2elcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 8 ALA A 202
ILE A  52
ALA A  53
LEU A 179
None
0.65A 5te8B-2elcA:
undetectable
5te8B-2elcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
5 / 12 PRO A 242
LEU A 240
VAL A 189
LEU A 300
TYR A 238
None
1.33A 6eliA-2elcA:
undetectable
6eliA-2elcA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus)
4 / 6 VAL A 324
LEU A 320
LEU A  95
LEU A 121
None
1.06A 6f6sA-2elcA:
undetectable
6f6sB-2elcA:
undetectable
6f6sA-2elcA:
17.21
6f6sB-2elcA:
10.94