SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ell'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 9 LEU A  67
ILE A  41
VAL A  59
GLY A  60
LEU A  56
 None
 1.16A 1e7aB-2ellA:
undetectable		 1e7aB-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		4 / 8 LEU A  31
ASN A  58
LEU A  61
LEU A  56
 None
 0.98A 1e7cA-2ellA:
undetectable		 1e7cA-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		4 / 5 SER A 124
GLU A 161
TYR A 155
ASP A 126
 None
 1.50A 1vidA-2ellA:
undetectable		 1vidA-2ellA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		3 / 3 LYS A  75
ASP A 153
ASN A 101
 None
 1.09A 2bm9A-2ellA:
undetectable		 2bm9A-2ellA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 11 LEU A  67
ILE A  41
VAL A  59
GLY A  60
LEU A  56
 None
 1.27A 2bxeA-2ellA:
undetectable		 2bxeA-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 12 LEU A  67
ILE A  41
VAL A  59
GLY A  60
LEU A  56
 None
 1.13A 2bxeB-2ellA:
undetectable		 2bxeB-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		4 / 6 LEU A 127
GLY A 104
LEU A 125
SER A 124
 None
 0.93A 3aiaA-2ellA:
undetectable		 3aiaA-2ellA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 8 LEU A  56
VAL A  64
LEU A  67
ILE A  83
LEU A  76
 None
 0.85A 3kp6A-2ellA:
undetectable
3kp6B-2ellA:
undetectable		 3kp6A-2ellA:
26.19
3kp6B-2ellA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		3 / 3 HIS A  99
VAL A 142
LEU A 149
 None
 0.75A 4m2vA-2ellA:
undetectable		 4m2vA-2ellA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 12 LEU A 113
LEU A 122
LEU A 102
ASN A 101
ILE A  83
 None
 1.05A 4x1iD-2ellA:
undetectable		 4x1iD-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A  97
LEU A 102
ASN A 101
ILE A  83
 None
 1.08A 4x1iD-2ellA:
undetectable		 4x1iD-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 12 LEU A 113
LEU A 122
LEU A 102
ASN A 101
ILE A  83
 None
 1.01A 4x1yD-2ellA:
undetectable		 4x1yD-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 11 LEU A 113
LEU A 122
LEU A 102
ASN A 101
ILE A  83
 None
 1.19A 4x20D-2ellA:
undetectable		 4x20D-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 11 LEU A 116
LEU A  97
LEU A 102
ASN A 101
ILE A  83
 None
 1.18A 4x20D-2ellA:
undetectable		 4x20D-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		4 / 5 SER A 124
GLU A 161
TYR A 155
ASP A 126
 None
 1.48A 5fhrA-2ellA:
undetectable		 5fhrA-2ellA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 12 LEU A  44
THR A  45
ALA A  46
ILE A  41
LEU A  70
 None
 0.99A 5nfjA-2ellA:
undetectable		 5nfjA-2ellA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A  97
LEU A 102
ASN A 101
ILE A  83
 None
 0.98A 5xiwB-2ellA:
undetectable		 5xiwB-2ellA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens) 		4 / 8 LEU A 146
LEU A 122
GLY A  86
LYS A 117
 None
 0.70A 6ce2A-2ellA:
undetectable		 6ce2A-2ellA:
22.35