SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA8_0
(GRAMICIDIN A)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 4 GLY A  71
VAL A 105
TRP A 169
TRP A 173
 None
 1.19A 1magA-2engA:
undetectable		 1magA-2engA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB8_0
(GRAMICIDIN A)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 4 GLY A  71
VAL A 105
TRP A 169
TRP A 173
 None
 1.19A 1magB-2engA:
undetectable		 1magB-2engA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		5 / 12 PHE A  72
LEU A  70
VAL A  64
PHE A  68
VAL A 105
 None
 1.20A 1q23B-2engA:
undetectable		 1q23B-2engA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		5 / 12 PHE A  72
LEU A  70
VAL A  64
PHE A  68
VAL A 105
 None
 1.23A 1q23H-2engA:
undetectable
1q23I-2engA:
undetectable		 1q23H-2engA:
20.50
1q23I-2engA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		3 / 3 GLY A 128
GLY A 144
GLY A 149
 None
 0.34A 3bogC-2engA:
undetectable		 3bogC-2engA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		3 / 3 GLY A 128
GLY A 144
GLY A 149
 None
 0.30A 3bogD-2engA:
undetectable		 3bogD-2engA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 8 GLY A 149
PHE A 182
PHE A  94
PHE A 174
 None
 1.04A 3ko0D-2engA:
undetectable
3ko0E-2engA:
undetectable		 3ko0D-2engA:
18.57
3ko0E-2engA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 8 PHE A 174
GLY A 149
PHE A 182
PHE A  94
 None
 1.10A 3ko0B-2engA:
undetectable
3ko0J-2engA:
undetectable		 3ko0B-2engA:
18.57
3ko0J-2engA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 7 GLY A 149
PHE A 182
PHE A  94
PHE A 174
 None
 1.14A 3ko0L-2engA:
undetectable
3ko0N-2engA:
undetectable		 3ko0L-2engA:
18.57
3ko0N-2engA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 7 PHE A 174
GLY A 149
PHE A 182
PHE A  94
 None
 1.13A 3ko0K-2engA:
undetectable
3ko0S-2engA:
undetectable		 3ko0K-2engA:
18.57
3ko0S-2engA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 7 PHE A 174
GLY A 149
PHE A 182
PHE A  94
 None
 1.12A 3ko0R-2engA:
undetectable
3ko0T-2engA:
undetectable		 3ko0R-2engA:
18.57
3ko0T-2engA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		3 / 3 GLY A  79
SER A  80
TRP A  85
 None
 0.98A 4e7cD-2engA:
undetectable		 4e7cD-2engA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		4 / 8 GLY A 128
ASP A 121
PRO A  61
THR A  60
 None
 0.87A 4eyrB-2engA:
undetectable		 4eyrB-2engA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2eng ENDOGLUCANASE V
(Humicola
insolens) 		5 / 12 ASP A  10
GLY A 130
TYR A   8
ASN A 179
THR A   6
 None
 1.34A 5x7pB-2engA:
0.0		 5x7pB-2engA:
10.91