SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 9 ILE A  34
GLY A  36
GLY A  37
SER A  74
LEU A  91
 None
 1.10A 2qmmA-2enoA:
undetectable		 2qmmA-2enoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  95
LEU A  30
LEU A 101
VAL A  75
ILE A  34
 None
 0.95A 3datA-2enoA:
undetectable		 3datA-2enoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 11 ALA A  95
GLY A  29
ASN A  76
LEU A  91
VAL A  89
 None
 0.96A 3dcmX-2enoA:
undetectable		 3dcmX-2enoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  95
LEU A  30
LEU A 101
VAL A  75
ILE A  34
 None
 0.91A 3fl9B-2enoA:
undetectable		 3fl9B-2enoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  95
LEU A  30
LEU A 101
SER A  74
ILE A  34
 None
 1.18A 3hj3A-2enoA:
undetectable		 3hj3A-2enoA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 11 ALA A  95
LEU A  30
LEU A 101
VAL A  75
ILE A  34
 None
 0.99A 3jw5A-2enoA:
undetectable		 3jw5A-2enoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  92
LEU A 101
LEU A  66
TYR A  50
LEU A  83
 None
 1.11A 5h8tA-2enoA:
undetectable		 5h8tA-2enoA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  92
LEU A 101
LEU A  66
TYR A  50
LEU A  83
 None
 1.00A 5ljeA-2enoA:
undetectable		 5ljeA-2enoA:
20.71