SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2enx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 10 LEU A 267
ALA A 219
ASP A 205
VAL A 221
ILE A 204
 None
None
MG  A 501 ( 4.0A)
None
None
 1.21A 1d4sA-2enxA:
undetectable		 1d4sA-2enxA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 10 ASP A  13
GLU A  46
ALA A 294
THR A 257
ASP A 205
 MN  A 401 (-2.6A)
None
None
None
MG  A 501 ( 4.0A)
 1.47A 1m4dA-2enxA:
0.0		 1m4dA-2enxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 9 ASP A  13
GLU A  46
ALA A 294
THR A 257
ASP A 205
 MN  A 401 (-2.6A)
None
None
None
MG  A 501 ( 4.0A)
 1.38A 1m4dB-2enxA:
0.0		 1m4dB-2enxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		3 / 3 ASP A 228
ASP A 258
ASN A 192
 None
 0.74A 2bm9D-2enxA:
undetectable		 2bm9D-2enxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		3 / 3 VAL A 238
GLU A 234
GLU A 235
 None
 0.75A 2nv4A-2enxA:
undetectable		 2nv4A-2enxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		4 / 5 LEU A  40
ALA A  16
ILE A  17
SER A  20
 None
MN  A 401 ( 3.9A)
None
None
 0.93A 2othA-2enxA:
undetectable		 2othA-2enxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		4 / 6 THR A 107
LEU A 111
VAL A  96
VAL A 102
 None
 0.92A 2z97A-2enxA:
undetectable		 2z97A-2enxA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		4 / 5 HIS A 100
ASP A  77
HIS A  99
ASP A  15
 2PN  A1001 (-3.9A)
MN  A 401 (-2.3A)
MN  A 402 ( 3.7A)
MN  A 402 (-3.2A)
 1.21A 3c0zA-2enxA:
undetectable		 3c0zA-2enxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		4 / 6 HIS A  99
HIS A 100
ASP A 151
ASP A  13
 MN  A 402 ( 3.7A)
2PN  A1001 (-3.9A)
MN  A 402 ( 2.7A)
MN  A 401 (-2.6A)
 1.18A 3c0zC-2enxA:
undetectable		 3c0zC-2enxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		4 / 7 LEU A 148
ASP A 164
GLU A 116
HIS A  99
 None
None
None
MN  A 402 ( 3.7A)
 1.18A 4aq7A-2enxA:
undetectable		 4aq7A-2enxA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 12 ASP A 164
GLY A 119
ALA A 121
GLY A 147
ASP A  15
 None
None
MN  A 402 ( 4.9A)
None
MN  A 402 (-3.2A)
 0.98A 4dc3A-2enxA:
undetectable		 4dc3A-2enxA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 12 VAL A  21
SER A 120
GLY A   8
GLY A 147
ASP A 151
 None
None
None
None
MN  A 402 ( 2.7A)
 1.34A 4pevB-2enxA:
undetectable		 4pevB-2enxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 12 VAL A 167
GLY A 119
TYR A 126
SER A 123
GLN A 300
 None
 1.46A 4xueB-2enxA:
undetectable		 4xueB-2enxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		5 / 12 PRO A  12
GLY A   8
ASP A 205
ILE A 204
ASP A  15
 None
None
MG  A 501 ( 4.0A)
None
MN  A 402 (-3.2A)
 1.21A 5wwsB-2enxA:
undetectable		 5wwsB-2enxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 155
ASN A 178
LEU A 184
 None
 0.77A 6exiD-2enxA:
undetectable		 6exiD-2enxA:
16.12