SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		3 / 3 THR A  54
LEU A  58
VAL A  61
 None
 0.26A 1mz9E-2eo4A:
undetectable		 1mz9E-2eo4A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 10 LEU A  37
ALA A  24
ILE A  39
VAL A  62
ALA A  59
 None
 1.12A 1xp0A-2eo4A:
undetectable		 1xp0A-2eo4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A  39
ALA A  23
ALA A  24
ARG A   9
ILE A  92
 None
None
None
None
PO4  A 202 ( 4.6A)
 1.16A 2aclC-2eo4A:
undetectable		 2aclC-2eo4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 HIS A  94
ASP A  53
THR A  54
HIS A  43
 ZN  A 201 ( 3.2A)
None
None
ZN  A 201 ( 3.1A)
 1.31A 2zxwA-2eo4A:
undetectable
2zxwC-2eo4A:
undetectable		 2zxwA-2eo4A:
13.62
2zxwC-2eo4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A  39
ALA A  23
ALA A  24
ARG A   9
ILE A  92
 None
None
None
None
PO4  A 202 ( 4.6A)
 1.06A 3falA-2eo4A:
undetectable		 3falA-2eo4A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		6 / 10 PHE A   3
ILE A   6
ASP A  27
LEU A  37
HIS A  96
HIS A  98
 None
None
None
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.51A 3o1cA-2eo4A:
13.0		 3o1cA-2eo4A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		6 / 10 PHE A   3
ILE A   6
ASP A  27
LEU A  37
HIS A  96
HIS A  98
 None
None
None
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.54A 3o1xA-2eo4A:
12.9		 3o1xA-2eo4A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		6 / 10 PHE A   3
ILE A   6
ASP A  27
LEU A  37
HIS A  96
HIS A  98
 None
None
None
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.54A 3qgzA-2eo4A:
13.0		 3qgzA-2eo4A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 PHE A 111
TYR A 107
VAL A  73
ILE A  69
 None
 1.05A 4a97H-2eo4A:
undetectable		 4a97H-2eo4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 111
TYR A 107
VAL A  73
ILE A  69
 None
 1.06A 4a97I-2eo4A:
undetectable		 4a97I-2eo4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 125
ILE A 132
ARG A 133
ILE A 131
 None
 0.86A 4lv9A-2eo4A:
undetectable		 4lv9A-2eo4A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ASN A  83
GLN A  90
HIS A  96
HIS A  98
 PO4  A 202 ( 3.8A)
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.24A 5km8A-2eo4A:
10.9
5km8B-2eo4A:
13.6		 5km8A-2eo4A:
22.28
5km8B-2eo4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		7 / 12 PHE A   3
ILE A   6
LEU A  11
ASP A  27
LEU A  37
HIS A  96
HIS A  98
 None
None
None
None
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.76A 5km9B-2eo4A:
13.6		 5km9B-2eo4A:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		7 / 12 PHE A   3
ILE A   6
ILE A  25
ASP A  27
LEU A  37
HIS A  96
HIS A  98
 None
None
None
None
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.46A 5uvmB-2eo4A:
13.7		 5uvmB-2eo4A:
33.12