SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ep5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A 265
GLY A 326
VAL A 287
ILE A 285
 None
 0.66A 1d4yB-2ep5A:
undetectable		 1d4yB-2ep5A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 261
THR A 176
LEU A 322
LEU A 212
ILE A 160
 None
 1.19A 1kqwA-2ep5A:
undetectable		 1kqwA-2ep5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 106
ASN A 148
GLY A 332
GLY A  17
 None
 0.63A 1me7A-2ep5A:
undetectable		 1me7A-2ep5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASN A 328
LEU A 329
ASP A 327
GLU A  54
 None
 0.99A 1mxgA-2ep5A:
undetectable		 1mxgA-2ep5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A 336
LEU A 339
VAL A 343
 None
 0.42A 1mz9B-2ep5A:
undetectable		 1mz9B-2ep5A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A 202
ILE A 198
THR A 176
 None
 0.65A 1rx3A-2ep5A:
undetectable		 1rx3A-2ep5A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 325
GLY A 305
ASN A 328
ASN A 301
ALA A 302
 None
 1.08A 2bm9C-2ep5A:
undetectable		 2bm9C-2ep5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 331
GLN A 273
PRO A 281
 None
 0.75A 2qhfA-2ep5A:
undetectable		 2qhfA-2ep5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 PRO A 162
ILE A 250
ASN A 216
LEU A 229
 None
 1.27A 2wekB-2ep5A:
5.3		 2wekB-2ep5A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  82
VAL A 341
ILE A   5
LEU A  65
TYR A  46
 None
 1.14A 3g9eA-2ep5A:
undetectable		 3g9eA-2ep5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 342
HIS A  27
THR A 279
 None
 0.86A 3hkuA-2ep5A:
undetectable		 3hkuA-2ep5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 106
ASN A 148
GLY A 332
GLY A  17
 None
 0.63A 4fo4B-2ep5A:
undetectable		 4fo4B-2ep5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A 202
ILE A 198
THR A 176
 None
 0.68A 4gh8A-2ep5A:
undetectable		 4gh8A-2ep5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 LYS A 133
LEU A 131
GLU A 130
LEU A 219
 None
 1.21A 4k4yA-2ep5A:
undetectable		 4k4yA-2ep5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 4 LYS A 133
LEU A 131
GLU A 130
LEU A 219
 None
 1.24A 4k4yE-2ep5A:
undetectable		 4k4yE-2ep5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 LYS A 133
LEU A 131
GLU A 130
LEU A 219
 None
 1.23A 4k4yI-2ep5A:
undetectable		 4k4yI-2ep5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 157
GLY A 305
ASP A 327
GLY A 335
 None
 0.91A 4koeA-2ep5A:
1.7
4koeB-2ep5A:
1.7
4koeC-2ep5A:
2.2		 4koeA-2ep5A:
22.09
4koeB-2ep5A:
22.09
4koeC-2ep5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 SER A 157
GLY A 305
ASP A 327
GLY A 335
 None
 0.95A 4koeA-2ep5A:
undetectable
4koeB-2ep5A:
undetectable
4koeD-2ep5A:
2.2		 4koeA-2ep5A:
22.09
4koeB-2ep5A:
22.09
4koeD-2ep5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 LEU A 271
PRO A 122
GLU A 346
TYR A 349
 None
 1.05A 4lb2A-2ep5A:
0.3		 4lb2A-2ep5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 304
ALA A 307
VAL A 308
 None
 0.68A 4o2bC-2ep5A:
undetectable		 4o2bC-2ep5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  80
LEU A   9
THR A 337
ILE A 338
LEU A  30
 None
 1.16A 4o5fA-2ep5A:
undetectable
4o5fB-2ep5A:
undetectable		 4o5fA-2ep5A:
22.80
4o5fB-2ep5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  30
VAL A  80
LEU A   9
THR A 337
ILE A 338
 None
 1.20A 4o5fA-2ep5A:
undetectable
4o5fB-2ep5A:
undetectable		 4o5fA-2ep5A:
22.80
4o5fB-2ep5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 304
ALA A 307
VAL A 308
 None
 0.61A 4x1iA-2ep5A:
2.2		 4x1iA-2ep5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 304
ALA A 307
VAL A 308
 None
 0.66A 4x20C-2ep5A:
3.1		 4x20C-2ep5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 GLY A 305
ASP A 327
GLY A 335
SER A 157
 None
 0.91A 4z53A-2ep5A:
undetectable
4z53B-2ep5A:
undetectable		 4z53A-2ep5A:
20.88
4z53B-2ep5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 305
ASP A 327
GLY A 335
SER A 157
 None
 0.96A 4z53A-2ep5A:
undetectable
4z53B-2ep5A:
undetectable		 4z53A-2ep5A:
20.88
4z53B-2ep5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  30
VAL A  80
LEU A   9
THR A 337
ILE A 338
 None
 1.23A 5b8hA-2ep5A:
undetectable
5b8hB-2ep5A:
undetectable		 5b8hA-2ep5A:
22.22
5b8hB-2ep5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 4 LEU A 119
TYR A 349
PRO A 122
ILE A 336
 None
 1.41A 5esgA-2ep5A:
undetectable		 5esgA-2ep5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A 248
ILE A 166
MET A 156
 None
 0.66A 5i9yA-2ep5A:
undetectable		 5i9yA-2ep5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 THR A 176
MET A 245
HIS A 244
 None
 0.94A 5uunA-2ep5A:
undetectable		 5uunA-2ep5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 304
ALA A 307
VAL A 308
 None
 0.54A 5xiwC-2ep5A:
undetectable		 5xiwC-2ep5A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A 182
GLN A 178
THR A 240
VAL A 300
 None
 0.83A 6czmD-2ep5A:
1.3
6czmF-2ep5A:
1.2		 6czmD-2ep5A:
22.19
6czmF-2ep5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 VAL A 117
THR A 337
ILE A 338
VAL A 341
MET A 344
 None
 1.36A 6hcoA-2ep5A:
undetectable
6hcoB-2ep5A:
undetectable		 6hcoA-2ep5A:
20.47
6hcoB-2ep5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASN A 121
GLN A 273
PRO A 122
ILE A 124
 None
 1.12A 6hzpA-2ep5A:
undetectable		 6hzpA-2ep5A:
21.93