SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ep7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ASN A 322
TYR A 326
ASN A 155
TYR A 320
 NAD  A 401 (-3.9A)
NAD  A 401 ( 3.7A)
None
None
 0.96A 1dssG-2ep7A:
27.0		 1dssG-2ep7A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		7 / 7 SER A 151
THR A 153
ASN A 155
CYH A 156
TYR A 320
ASN A 322
TYR A 326
 None
None
None
None
None
NAD  A 401 (-3.9A)
NAD  A 401 ( 3.7A)
 0.23A 1dssG-2ep7A:
27.0		 1dssG-2ep7A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 ASN A 322
TYR A 326
ASN A 155
TYR A 320
 NAD  A 401 (-3.9A)
NAD  A 401 ( 3.7A)
None
None
 0.95A 1dssR-2ep7A:
26.9		 1dssR-2ep7A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		8 / 8 SER A 151
THR A 153
ASN A 155
CYH A 156
HIS A 179
TYR A 320
ASN A 322
TYR A 326
 None
None
None
None
None
None
NAD  A 401 (-3.9A)
NAD  A 401 ( 3.7A)
 0.42A 1dssR-2ep7A:
26.9		 1dssR-2ep7A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 PHE A  10
VAL A  67
VAL A  74
ILE A  32
 None
 0.98A 1t87B-2ep7A:
undetectable		 1t87B-2ep7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ALA A 318
ILE A 316
ILE A 242
ALA A 213
LEU A 223
 None
 1.02A 1uduB-2ep7A:
undetectable		 1uduB-2ep7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ASN A 135
VAL A 134
TYR A 269
LEU A 330
SER A 299
 None
 1.06A 2iyfB-2ep7A:
5.4		 2iyfB-2ep7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 ARG A  12
HIS A  51
SER A  16
ASP A 321
 None
 1.30A 2rk8A-2ep7A:
undetectable		 2rk8A-2ep7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ARG A  12
HIS A  51
SER A  16
ASP A 321
 None
 1.37A 2rk8B-2ep7A:
undetectable		 2rk8B-2ep7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 TYR A 139
ILE A 128
LEU A 337
VAL A 334
LEU A 333
 None
 1.42A 2w98A-2ep7A:
4.2		 2w98A-2ep7A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 ASN A 322
TYR A 326
ASN A 155
TYR A 320
 NAD  A 401 (-3.9A)
NAD  A 401 ( 3.7A)
None
None
 0.97A 3dmtC-2ep7A:
46.8		 3dmtC-2ep7A:
48.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		8 / 8 SER A 151
THR A 153
ASN A 155
CYH A 156
HIS A 179
TYR A 320
ASN A 322
TYR A 326
 None
None
None
None
None
None
NAD  A 401 (-3.9A)
NAD  A 401 ( 3.7A)
 0.32A 3dmtC-2ep7A:
46.8		 3dmtC-2ep7A:
48.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 CYH A 284
LEU A 306
ILE A 293
ILE A 288
LEU A 281
 None
 1.02A 3gwxA-2ep7A:
undetectable		 3gwxA-2ep7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 4 GLY A 173
TYR A 174
GLY A 229
ASP A 228
 None
 1.24A 3kl3A-2ep7A:
undetectable		 3kl3A-2ep7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 ASN A 155
LEU A 333
ASN A 149
ILE A 147
 None
 1.03A 4k0bA-2ep7A:
undetectable		 4k0bA-2ep7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 ASN A 155
LEU A 333
ASN A 149
ILE A 147
 None
 1.00A 4l7iA-2ep7A:
undetectable		 4l7iA-2ep7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 ASN A 135
VAL A 134
TYR A 269
LEU A 330
SER A 299
 None
 1.04A 4m83A-2ep7A:
undetectable		 4m83A-2ep7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 SER A 151
LEU A 157
PRO A 159
VAL A 131
THR A 129
 None
 1.19A 4uuuB-2ep7A:
undetectable		 4uuuB-2ep7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 THR A 209
THR A 208
PHE A 195
 None
 0.87A 5cxvA-2ep7A:
undetectable		 5cxvA-2ep7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 THR A 154
ALA A 150
ASN A 155
 None
 0.62A 5ersA-2ep7A:
2.1		 5ersA-2ep7A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 PRO A  84
THR A  97
PHE A 100
GLN A  82
ASN A  33
 None
NAD  A 401 (-4.0A)
NAD  A 401 (-4.7A)
None
NAD  A 401 (-4.2A)
 1.33A 5hgcA-2ep7A:
undetectable		 5hgcA-2ep7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 VAL A 219
THR A 129
TYR A 320
GLY A 211
ALA A 215
 None
 0.99A 5mxbA-2ep7A:
undetectable		 5mxbA-2ep7A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 GLY A  14
ILE A  13
ASP A  48
HIS A  51
 None
NAD  A 401 (-4.2A)
None
None
 0.92A 6ag0A-2ep7A:
undetectable		 6ag0A-2ep7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 ARG A  19
HIS A  51
ARG A  12
 None
 1.18A 6dwdD-2ep7A:
undetectable		 6dwdD-2ep7A:
19.58