SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2epg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 5 ARG A 297
ALA A 295
ASP A 325
GLY A 174
 None
 0.94A 1e7bA-2epgA:
undetectable		 1e7bA-2epgA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 9 LEU A  60
ALA A  61
LEU A  46
MET A  47
LEU A  35
 None
 1.32A 1gwrB-2epgA:
0.0		 1gwrB-2epgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 5 HIS A 204
ARG A 239
ILE A 170
HIS A 328
 None
 0.96A 1osvB-2epgA:
0.0		 1osvB-2epgA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		3 / 3 SER A 397
GLU A 457
ASP A 216
 None
 0.75A 2avdB-2epgA:
undetectable		 2avdB-2epgA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		3 / 3 ARG A 191
VAL A 250
GLY A  91
 None
 0.63A 2avvE-2epgA:
undetectable		 2avvE-2epgA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 7 HIS A 328
ALA A 348
ASP A  64
GLY A  74
GLY A 347
 None
 1.48A 2c49B-2epgA:
undetectable		 2c49B-2epgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 ALA A 285
ALA A 193
GLY A 192
ALA A 188
ASP A 248
 None
 1.13A 2f16H-2epgA:
undetectable
2f16I-2epgA:
undetectable		 2f16H-2epgA:
20.87
2f16I-2epgA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 ALA A 285
ALA A 193
GLY A 192
ALA A 188
ASP A 248
 None
 1.15A 2f16V-2epgA:
undetectable
2f16W-2epgA:
undetectable		 2f16V-2epgA:
20.87
2f16W-2epgA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 8 TYR A 210
ASP A 212
TYR A 381
TYR A 379
 None
 1.47A 2ha2A-2epgA:
undetectable		 2ha2A-2epgA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 8 TYR A 210
ASP A 212
TYR A 381
TYR A 379
 None
 1.49A 2ha2B-2epgA:
undetectable		 2ha2B-2epgA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 ALA A 301
LEU A 206
VAL A 232
LEU A 119
PHE A 308
 None
 1.22A 3fl9C-2epgA:
undetectable		 3fl9C-2epgA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 LEU A 176
ILE A  55
VAL A  92
LEU A 283
ILE A 274
 None
 1.13A 3gwxB-2epgA:
undetectable		 3gwxB-2epgA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 LEU A 176
ASN A 291
GLY A 174
VAL A 167
ARG A 350
 None
 1.24A 3h52A-2epgA:
undetectable		 3h52A-2epgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 ALA A 285
ALA A 193
GLY A 192
ALA A 188
ASP A 248
 None
 1.08A 3mg0V-2epgA:
undetectable
3mg0W-2epgA:
undetectable		 3mg0V-2epgA:
20.87
3mg0W-2epgA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 GLY A 224
ASP A 212
LEU A 468
ARG A 467
VAL A 382
 None
 1.06A 3o7wA-2epgA:
undetectable		 3o7wA-2epgA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 GLY A 347
GLY A  74
VAL A  76
ALA A 327
GLU A 171
 None
 1.17A 3p2kB-2epgA:
undetectable		 3p2kB-2epgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 10 SER A 105
PHE A 308
LEU A 206
VAL A 474
VAL A 304
 None
 1.44A 3u9fR-2epgA:
1.0		 3u9fR-2epgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 10 LEU A 176
GLY A  99
ASP A  95
GLY A 237
SER A 238
 None
 1.09A 4bwlC-2epgA:
undetectable		 4bwlC-2epgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 6 GLY A 279
VAL A  87
PRO A 273
GLY A  84
 None
 0.77A 4dxuA-2epgA:
undetectable		 4dxuA-2epgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 7 GLY A 279
VAL A  87
PRO A 273
GLY A  84
 None
 0.76A 4forA-2epgA:
undetectable		 4forA-2epgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 7 PRO A 354
ALA A 219
PHE A 223
TYR A 324
 None
 0.99A 4lb2A-2epgA:
undetectable		 4lb2A-2epgA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		3 / 3 MET A  47
GLN A 268
TYR A  69
 None
 1.01A 4udcA-2epgA:
undetectable		 4udcA-2epgA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 LEU A 241
PHE A 292
ALA A 289
THR A 236
ILE A 300
 None
 1.31A 4uuuA-2epgA:
undetectable
4uuuB-2epgA:
undetectable		 4uuuA-2epgA:
15.38
4uuuB-2epgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 LEU A 371
LEU A 468
LEU A 323
VAL A 465
ALA A 466
 None
 0.98A 4x1yD-2epgA:
undetectable		 4x1yD-2epgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 9 GLN A 368
LEU A 326
LEU A 323
LEU A 371
ARG A 101
 None
 1.45A 4x30A-2epgA:
undetectable		 4x30A-2epgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 7 ARG A 350
ARG A 297
ASP A 325
ILE A 170
 None
 1.14A 5a06B-2epgA:
undetectable		 5a06B-2epgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 10 LEU A  60
ALA A  61
LEU A  46
MET A  47
LEU A  35
 None
 1.29A 5dx3A-2epgA:
undetectable		 5dx3A-2epgA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 LEU A  60
ALA A  61
LEU A  46
MET A  47
LEU A  35
 None
 1.23A 5dxgB-2epgA:
undetectable		 5dxgB-2epgA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		4 / 7 ALA A 389
THR A 386
VAL A 370
LYS A 463
 None
 1.05A 5ecnA-2epgA:
undetectable		 5ecnA-2epgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 ALA A 122
VAL A 311
LEU A 107
SER A 105
ILE A 234
 None
 1.23A 5hv1A-2epgA:
undetectable		 5hv1A-2epgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 11 LEU A  60
ALA A  61
LEU A  46
MET A  47
LEU A  35
 None
 1.28A 5hyrB-2epgA:
undetectable		 5hyrB-2epgA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		3 / 3 ARG A 187
HIS A 243
ARG A 191
 None
 0.82A 5iaoC-2epgA:
undetectable		 5iaoC-2epgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		3 / 3 ARG A 187
HIS A 243
ARG A 191
 None
 0.83A 5iaoF-2epgA:
undetectable		 5iaoF-2epgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 7 LEU A 156
LEU A 176
ILE A 196
GLY A 197
ILE A  96
 None
 1.39A 5vkqA-2epgA:
undetectable
5vkqB-2epgA:
undetectable		 5vkqA-2epgA:
14.11
5vkqB-2epgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 12 GLY A 385
THR A 386
GLY A 353
LYS A 464
LEU A 225
 None
 1.09A 5ybbA-2epgA:
undetectable		 5ybbA-2epgA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2epg HYPOTHETICAL PROTEIN
TTHA1785
(Thermus
thermophilus) 		5 / 10 LEU A  60
ALA A  61
LEU A  46
MET A  47
LEU A  35
 None
 1.27A 6cbzB-2epgA:
undetectable		 6cbzB-2epgA:
12.24