SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2epj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 ALA A 154
ASP A 153
GLY A 150
ILE A 241
ILE A 129
 None
None
PMP  A 501 ( 3.9A)
None
None
 0.93A 1hshC-2epjA:
undetectable		 1hshC-2epjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 8 TYR A 327
GLY A 248
GLY A 255
GLY A 252
LEU A 251
 None
 0.97A 1qzzA-2epjA:
undetectable		 1qzzA-2epjA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 GLY A 258
GLU A 254
ASN A 261
 None
 0.67A 1zq9A-2epjA:
undetectable		 1zq9A-2epjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 5 ILE A 272
PRO A  67
PHE A 407
VAL A 246
 None
None
None
PMP  A 501 ( 4.5A)
 1.23A 2hjhB-2epjA:
0.3		 2hjhB-2epjA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 THR A 353
ARG A 377
ASN A 372
SER A 371
PHE A 364
 None
 1.37A 2vdyB-2epjA:
undetectable		 2vdyB-2epjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 5 TYR A 352
ILE A 365
LEU A 432
LEU A 428
 None
 1.08A 2zb7A-2epjA:
undetectable		 2zb7A-2epjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 279
LEU A 101
ILE A 105
ILE A  69
GLY A  66
 None
 1.27A 3cv9A-2epjA:
undetectable		 3cv9A-2epjA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 7 PHE A 397
GLU A 404
SER A 401
VAL A  31
 None
 1.46A 3dqtA-2epjA:
undetectable
3dqtB-2epjA:
undetectable		 3dqtA-2epjA:
22.55
3dqtB-2epjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 LEU A 251
GLY A 258
LEU A 226
ARG A 223
PHE A 260
 None
 1.41A 3h52C-2epjA:
undetectable		 3h52C-2epjA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 8 LEU A  50
ARG A  32
GLY A  66
PRO A  67
 None
 1.10A 3hcrA-2epjA:
2.6		 3hcrA-2epjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 ILE A 273
GLY A 274
GLY A 275
ALA A 312
VAL A 279
 None
 0.81A 3jb2A-2epjA:
2.1		 3jb2A-2epjA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 SER A 120
GLY A 121
THR A 122
 PMP  A 501 ( 3.8A)
PMP  A 501 ( 3.3A)
PMP  A 501 ( 3.5A)
 0.18A 3k9wA-2epjA:
undetectable		 3k9wA-2epjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 GLY A 276
GLY A 275
VAL A 279
LEU A 101
GLY A  66
 None
 0.88A 4dc3B-2epjA:
undetectable		 4dc3B-2epjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 10 ARG A 425
ALA A 340
LEU A 424
GLY A 423
ALA A 214
 None
 1.49A 4fe1A-2epjA:
undetectable
4fe1J-2epjA:
undetectable		 4fe1A-2epjA:
21.85
4fe1J-2epjA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.31A 4mmbA-2epjA:
undetectable		 4mmbA-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.39A 4mmeA-2epjA:
undetectable		 4mmeA-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.35A 4mmeB-2epjA:
undetectable		 4mmeB-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.29A 4mmfA-2epjA:
undetectable		 4mmfA-2epjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.26A 4mmfB-2epjA:
undetectable		 4mmfB-2epjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 VAL A 218
ALA A 216
PHE A 364
 None
 0.75A 4olbA-2epjA:
2.6		 4olbA-2epjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 LEU A 229
SER A 233
ALA A 238
LEU A 142
PHE A 144
 None
 1.42A 4qdcA-2epjA:
0.0		 4qdcA-2epjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 VAL A 218
ALA A 216
PHE A 364
 None
 0.69A 4w5nA-2epjA:
2.4		 4w5nA-2epjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 VAL A 218
ALA A 216
PHE A 364
 None
 0.74A 4z4iA-2epjA:
2.3		 4z4iA-2epjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 ALA A 256
TYR A 259
PRO A 220
 None
 0.72A 4zdyA-2epjA:
undetectable		 4zdyA-2epjA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 LEU A 363
LEU A 424
ARG A 331
 None
 0.61A 5hnzB-2epjA:
undetectable		 5hnzB-2epjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 VAL A 218
ALA A 216
PHE A 364
 None
 0.73A 5js1A-2epjA:
2.4		 5js1A-2epjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 ARG A 231
PHE A 260
LEU A 240
 None
 0.80A 5veuA-2epjA:
undetectable		 5veuA-2epjA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 5 LEU A 232
PHE A 197
LEU A 193
PHE A 225
 None
 0.99A 5x19C-2epjA:
undetectable
5x19J-2epjA:
undetectable		 5x19C-2epjA:
19.55
5x19J-2epjA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 6 GLY A 201
TYR A 200
LEU A 232
VAL A 207
 None
 0.98A 5x80A-2epjA:
0.7
5x80B-2epjA:
undetectable		 5x80A-2epjA:
18.99
5x80B-2epjA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 5 GLU A 210
HIS A 149
LEU A 156
VAL A 155
 PMP  A 501 ( 3.9A)
None
None
None
 0.96A 6bc9A-2epjA:
undetectable		 6bc9A-2epjA:
9.51