SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 6 ALA A  85
ILE A  48
PRO A  84
GLU A  54
 None
 1.15A 1oniB-2eq5A:
undetectable
1oniC-2eq5A:
undetectable		 1oniB-2eq5A:
21.27
1oniC-2eq5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A  85
ILE A  41
ILE A  48
GLU A  54
 None
 0.74A 1oniD-2eq5A:
undetectable
1oniF-2eq5A:
undetectable		 1oniD-2eq5A:
21.27
1oniF-2eq5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  48
PRO A  84
GLU A  54
ALA A  85
 None
 1.15A 1oniD-2eq5A:
undetectable
1oniE-2eq5A:
undetectable		 1oniD-2eq5A:
21.27
1oniE-2eq5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 207
SER A 206
ILE A   6
PRO A  32
ALA A  30
 None
 0.97A 1vq1B-2eq5A:
undetectable		 1vq1B-2eq5A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A  70
THR A   5
VAL A  73
LEU A  93
ILE A  76
 None
 1.25A 2fj1A-2eq5A:
undetectable		 2fj1A-2eq5A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 190
GLU A 194
GLU A 193
 None
 0.80A 2nv4A-2eq5A:
undetectable		 2nv4A-2eq5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 10 THR A 124
VAL A 104
VAL A 115
ILE A 175
VAL A 174
 None
 1.23A 2qboA-2eq5A:
undetectable		 2qboA-2eq5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
SER A 206
ALA A 210
ILE A  27
LEU A   8
 None
 0.98A 3adxB-2eq5A:
undetectable		 3adxB-2eq5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 178
SER A 183
THR A 184
SER A  79
ALA A 100
 None
 1.21A 3d91A-2eq5A:
undetectable		 3d91A-2eq5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 112
VAL A 117
GLY A 116
ILE A 137
ILE A 197
 None
 0.89A 3ekqA-2eq5A:
undetectable		 3ekqA-2eq5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 132
LEU A 118
LEU A 120
SER A 105
GLY A 101
 None
 1.05A 3g2oB-2eq5A:
undetectable		 3g2oB-2eq5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A  31
LEU A  34
PRO A  32
GLU A  33
 None
 1.28A 3vlnA-2eq5A:
undetectable		 3vlnA-2eq5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A  98
ALA A  75
HIS A 212
ARG A 217
 None
 1.05A 4ac9B-2eq5A:
3.5
4ac9C-2eq5A:
3.5		 4ac9B-2eq5A:
19.59
4ac9C-2eq5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A  98
ALA A  75
HIS A 212
ARG A 217
 None
 1.12A 4acaB-2eq5A:
3.5
4acaC-2eq5A:
undetectable		 4acaB-2eq5A:
19.59
4acaC-2eq5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A 215
LEU A  34
GLU A  33
TYR A   4
 None
 1.33A 4olaA-2eq5A:
3.6		 4olaA-2eq5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A 215
LEU A  34
GLU A  33
TYR A   4
 None
 1.39A 4olbA-2eq5A:
0.0		 4olbA-2eq5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  86
ASP A  83
GLY A 101
ALA A 100
ILE A  77
 None
 0.89A 4xdrA-2eq5A:
undetectable		 4xdrA-2eq5A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 101
SER A 206
ALA A 210
ILE A  27
LEU A   8
 None
 0.97A 4xumB-2eq5A:
undetectable		 4xumB-2eq5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 180
HIS A 212
LEU A 107
 None
 0.69A 5axdA-2eq5A:
2.0		 5axdA-2eq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 180
HIS A 212
LEU A 107
 None
 0.69A 5axdC-2eq5A:
undetectable		 5axdC-2eq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
LEU A 177
ILE A  98
ILE A  78
GLY A 181
 None
 1.00A 5d4uC-2eq5A:
undetectable		 5d4uC-2eq5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 7 VAL A 104
SER A 105
ALA A 108
GLY A 116
 None
 0.68A 5fpdB-2eq5A:
2.5		 5fpdB-2eq5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A 215
LEU A  34
GLU A  33
TYR A   4
 None
 1.25A 5js1A-2eq5A:
4.6		 5js1A-2eq5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A 215
LEU A  34
GLU A  33
TYR A   4
 None
 1.26A 6cbdA-2eq5A:
2.9		 6cbdA-2eq5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE
(Pyrococcus
horikoshii) 		5 / 11 SER A 183
GLY A  99
GLY A 101
ASP A  83
VAL A 127
 None
 1.22A 6i5zD-2eq5A:
undetectable		 6i5zD-2eq5A:
20.99