SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		3 / 3 PHE A  57
LEU A  12
LEU A   8
 None
 0.62A 1mx1E-2eqlA:
undetectable		 1mx1E-2eqlA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		4 / 6 MET A  31
HIS A 114
ASP A 117
TYR A 123
 None
 1.04A 2lh8A-2eqlA:
undetectable		 2lh8A-2eqlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		4 / 7 TRP A  28
LEU A  59
LEU A  83
ILE A  92
 None
 1.02A 3u5jA-2eqlA:
undetectable		 3u5jA-2eqlA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4II8_A_010A210_0
(LYSOZYME C)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		6 / 7 GLU A  35
ASP A  53
GLN A  58
ASN A  60
TRP A  64
TRP A 108
 None
 0.39A 4ii8A-2eqlA:
22.7		 4ii8A-2eqlA:
49.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		4 / 8 ASP A  91
ALA A  95
VAL A  98
GLU A  35
 None
 0.82A 4zbqA-2eqlA:
undetectable		 4zbqA-2eqlA:
12.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DL9_A_ACTA214_0
(LYSOZYME C)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		4 / 5 GLU A  35
ASP A  53
TRP A 108
ALA A 110
 None
 0.63A 5dl9A-2eqlA:
22.5		 5dl9A-2eqlA:
49.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		3 / 3 HIS A 114
GLU A  33
ASN A  37
 None
 1.00A 5wbvA-2eqlA:
undetectable		 5wbvA-2eqlA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		3 / 3 HIS A 114
GLU A  33
ASN A  37
 None
 1.00A 5wbvB-2eqlA:
undetectable		 5wbvB-2eqlA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		4 / 5 LEU A  56
LYS A   1
LEU A   8
GLU A   7
 None
 1.26A 5weaA-2eqlA:
undetectable		 5weaA-2eqlA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2eql HORSE MILK LYSOZYME
(Equus
caballus) 		4 / 7 CSS A  94
CSS A  76
TRP A 108
LEU A  59
 None
 1.33A 6cnkB-2eqlA:
undetectable
6cnkC-2eqlA:
undetectable		 6cnkB-2eqlA:
20.77
6cnkC-2eqlA:
16.28