SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2erc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLU A  36
GLY A  38
GLY A  40
ASP A  84
ILE A  85
 None
 0.67A 1qaoA-2ercA:
31.0		 1qaoA-2ercA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLU A  36
ILE A  60
LEU A  64
ASP A  84
ILE A  85
 None
 0.82A 1qaoA-2ercA:
31.0		 1qaoA-2ercA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		5 / 12 ILE A  60
ASP A  61
LEU A  64
ASP A  84
ILE A  85
 None
 0.79A 1qaoA-2ercA:
31.0		 1qaoA-2ercA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLU A  36
GLY A  38
GLY A  40
ILE A  58
GLU A  59
ASP A  84
 None
 0.91A 3dxyA-2ercA:
10.9		 3dxyA-2ercA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLY A  38
GLY A  40
GLU A  59
ILE A  60
LEU A  64
ASP A  84
 None
 1.20A 3grvA-2ercA:
20.9		 3grvA-2ercA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLY A  38
GLY A  40
GLU A  59
LEU A  64
ASN A 101
ILE A 110
 None
 1.13A 3grvA-2ercA:
20.9		 3grvA-2ercA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		7 / 12 GLU A  36
GLY A  38
GLY A  40
GLU A  59
ILE A  60
LEU A  64
ASP A  84
 None
 1.26A 3gryA-2ercA:
20.8		 3gryA-2ercA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		6 / 12 GLU A  36
GLY A  38
GLY A  40
GLU A  59
LEU A  64
ASN A 101
 None
 1.07A 3gryA-2ercA:
20.8		 3gryA-2ercA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		4 / 6 ILE A 221
LEU A 235
LYS A 209
PHE A 207
 None
 1.03A 3sj1X-2ercA:
undetectable		 3sj1X-2ercA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		4 / 5 THR A 108
ILE A 111
PHE A 131
LEU A 142
 None
 1.42A 3tf1A-2ercA:
2.2		 3tf1A-2ercA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		4 / 8 TYR A 203
TRP A 198
VAL A 199
ILE A 227
 None
 1.23A 4bqtC-2ercA:
undetectable
4bqtD-2ercA:
undetectable		 4bqtC-2ercA:
21.48
4bqtD-2ercA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		4 / 8 LEU A 216
TYR A 203
TRP A 198
LEU A 235
 None
 0.96A 4puoC-2ercA:
undetectable		 4puoC-2ercA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		4 / 8 LEU A 216
TYR A 203
TRP A 198
LEU A 235
 None
 0.96A 4pwdA-2ercA:
undetectable		 4pwdA-2ercA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		5 / 12 PHE A 163
TYR A 162
PRO A 103
ILE A 154
ILE A  22
 None
 1.20A 5hbsA-2ercA:
undetectable		 5hbsA-2ercA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2erc RRNA METHYL
TRANSFERASE
(Bacillus
subtilis) 		3 / 3 TYR A 129
LEU A 136
ASP A 151
 None
 0.71A 5zv2B-2ercA:
undetectable		 5zv2B-2ercA:
12.70