SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2erq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 11 LEU A 306
ALA A 367
ALA A 360
MET A 359
HIS A 322
 None
 1.41A 1iiuA-2erqA:
undetectable		 1iiuA-2erqA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 7 VAL A 319
ILE A 318
HIS A 285
LEU A 279
 None
 0.87A 1j96B-2erqA:
undetectable		 1j96B-2erqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.18A 1os2A-2erqA:
9.7		 1os2A-2erqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.16A 1os2D-2erqA:
9.7		 1os2D-2erqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		6 / 10 THR A 300
HIS A 335
GLU A 336
HIS A 339
HIS A 345
ALA A 362
 None
ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.67A 1r55A-2erqA:
32.0		 1r55A-2erqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.25A 1uttA-2erqA:
10.1		 1uttA-2erqA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.19A 1utzA-2erqA:
9.9		 1utzA-2erqA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.22A 1utzB-2erqA:
10.0		 1utzB-2erqA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		3 / 3 ARG A 225
TYR A 215
LYS A 214
 None
 0.98A 1uujB-2erqA:
undetectable		 1uujB-2erqA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 6 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.16A 1y93A-2erqA:
10.2		 1y93A-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.16A 2hu6A-2erqA:
10.1		 2hu6A-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 9 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.75A 2jihA-2erqA:
26.6		 2jihA-2erqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 8 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.72A 2jihB-2erqA:
26.3		 2jihB-2erqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 6 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.20A 2ow9A-2erqA:
9.8		 2ow9A-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.21A 2ow9B-2erqA:
9.5		 2ow9B-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.22A 2ozrC-2erqA:
9.3		 2ozrC-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.25A 2ozrD-2erqA:
9.4		 2ozrD-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.39A 2ozrE-2erqA:
9.4		 2ozrE-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		3 / 3 HIS A 335
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.33A 2ozrF-2erqA:
9.3		 2ozrF-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 GLY A 304
GLU A 336
ILE A 318
ALA A 316
ASP A 265
 None
ZN  A 700 ( 4.3A)
None
None
None
 1.23A 2vdvE-2erqA:
undetectable		 2vdvE-2erqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 11 GLY A 304
GLU A 336
ILE A 318
ALA A 316
ASP A 265
 None
ZN  A 700 ( 4.3A)
None
None
None
 1.23A 2vdvF-2erqA:
undetectable		 2vdvF-2erqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.33A 2xinA-2erqA:
undetectable		 2xinA-2erqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.29A 2xinB-2erqA:
undetectable		 2xinB-2erqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.27A 2xinC-2erqA:
undetectable		 2xinC-2erqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.31A 2xinD-2erqA:
undetectable		 2xinD-2erqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		3 / 3 TYR A 538
TYR A 560
ILE A 574
 None
 0.79A 3eteA-2erqA:
2.9
3eteB-2erqA:
2.8		 3eteA-2erqA:
21.32
3eteB-2erqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 9 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.57A 3hy7A-2erqA:
26.7		 3hy7A-2erqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 9 HIS A 335
GLU A 336
HIS A 339
HIS A 345
LEU A 363
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
None
 0.44A 3hy7B-2erqA:
25.6		 3hy7B-2erqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.21A 3kecA-2erqA:
9.7		 3kecA-2erqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		3 / 3 HIS A 335
GLU A 336
HIS A 339
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
 0.12A 3kecB-2erqA:
9.5		 3kecB-2erqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.16A 3likA-2erqA:
10.1		 3likA-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.17A 3lilA-2erqA:
10.1		 3lilA-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.17A 3ljgA-2erqA:
10.1		 3ljgA-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.12A 3lkaA-2erqA:
10.1		 3lkaA-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		3 / 3 PRO A 563
SER A 565
ASN A 570
 None
 0.83A 3lslG-2erqA:
undetectable		 3lslG-2erqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 6 THR A 312
ASN A 311
GLY A 308
ILE A 391
 None
 0.91A 3w9tF-2erqA:
undetectable		 3w9tF-2erqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.34A 3ximB-2erqA:
undetectable		 3ximB-2erqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.37A 3ximD-2erqA:
undetectable		 3ximD-2erqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 6 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.26A 4a7bA-2erqA:
9.5		 4a7bA-2erqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		3 / 3 LEU A 291
LEU A 279
ASN A 287
 None
 0.64A 4otwA-2erqA:
undetectable		 4otwA-2erqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.37A 4xiaB-2erqA:
undetectable		 4xiaB-2erqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 PHE A 410
GLU A 415
VAL A 413
GLU A 480
GLY A 446
 None
CA  A 701 (-2.3A)
None
None
None
 1.40A 4ydqB-2erqA:
2.5		 4ydqB-2erqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 ALA A 264
THR A 267
GLY A 298
PRO A 299
ALA A 301
 None
 1.22A 4ypmA-2erqA:
1.9		 4ypmA-2erqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 7 LEU A 383
PRO A 388
LEU A 195
TYR A 194
 None
 0.93A 4z4fA-2erqA:
4.3		 4z4fA-2erqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.15A 5n5jA-2erqA:
10.2		 5n5jA-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.13A 5n5kA-2erqA:
10.2		 5n5kA-2erqA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 7 LEU A 383
PRO A 388
LEU A 195
TYR A 194
 None
 0.95A 5t7bA-2erqA:
4.2		 5t7bA-2erqA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 5 PRO A 588
GLY A 589
THR A 590
LYS A 591
 None
 1.18A 5x23A-2erqA:
undetectable		 5x23A-2erqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.41A 5ximA-2erqA:
undetectable		 5ximA-2erqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 HIS A 238
THR A 234
GLU A 412
GLU A 415
ASP A 418
 None
None
CA  A 701 (-3.0A)
CA  A 701 (-2.3A)
CA  A 701 (-3.7A)
 1.37A 5ximC-2erqA:
undetectable		 5ximC-2erqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 PHE A 410
GLU A 415
VAL A 413
GLU A 480
GLY A 446
 None
CA  A 701 (-2.3A)
None
None
None
 1.42A 5xioA-2erqA:
2.7		 5xioA-2erqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 6 PRO A 588
GLY A 589
THR A 590
LYS A 591
 None
 1.09A 5xxiA-2erqA:
undetectable		 5xxiA-2erqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 12 LEU A 383
GLY A 338
LEU A 203
ILE A 242
LEU A 268
 None
 1.23A 5y2tA-2erqA:
undetectable		 5y2tA-2erqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		4 / 7 SER A 315
GLY A 308
ARG A 275
LEU A 280
 None
 1.14A 6btxA-2erqA:
undetectable		 6btxA-2erqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1
(Crotalus
atrox) 		5 / 11 VAL A 329
ALA A 332
ASP A 208
ALA A 301
LEU A 363
 None
 1.42A 6dk1B-2erqA:
undetectable		 6dk1B-2erqA:
18.37