SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2erx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		3 / 3 PHE A  32
LEU A  23
SER A 151
 GDP  A 401 (-4.3A)
None
GDP  A 401 (-3.2A)
 0.71A 1e7aA-2erxA:
undetectable		 1e7aA-2erxA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		5 / 12 THR A  39
GLY A  19
GLY A  17
GLY A  64
ASP A 124
 MG  A 403 ( 3.0A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.3A)
PO4  A 402 (-3.3A)
GDP  A 401 (-2.9A)
 1.05A 2b25A-2erxA:
undetectable		 2b25A-2erxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		4 / 7 LEU A 161
LEU A 165
PHE A 162
LEU A  23
 None
 0.99A 2vq5B-2erxA:
undetectable		 2vq5B-2erxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		4 / 6 VAL A  10
LEU A  74
ILE A  48
ILE A  59
 None
 0.87A 3gcsA-2erxA:
undetectable		 3gcsA-2erxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		3 / 3 ARG A 171
TYR A   8
GLU A 169
 None
 0.68A 4zzbE-2erxA:
undetectable		 4zzbE-2erxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		3 / 3 LEU A 139
ALA A 138
LEU A  94
 None
 0.31A 5uunB-2erxA:
undetectable		 5uunB-2erxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		4 / 6 TYR A  36
GLU A  34
GLY A  17
GLY A  16
 PO4  A 402 ( 4.4A)
None
GDP  A 401 (-3.3A)
PO4  A 402 (-3.6A)
 0.91A 5x7pB-2erxA:
3.2		 5x7pB-2erxA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		4 / 5 VAL A 174
PHE A 147
MET A 148
GLY A 120
 None
 1.31A 6hd4A-2erxA:
undetectable		 6hd4A-2erxA:
18.40