SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ery'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		3 / 3 PHE A  39
LEU A  30
SER A 157
 GDP  A   1 (-4.1A)
None
GDP  A   1 (-3.3A)
 0.71A 1e7aA-2eryA:
undetectable		 1e7aA-2eryA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		5 / 12 ASP A 118
GLU A 119
MET A 122
PRO A 121
ILE A 111
 None
 1.42A 1s14A-2eryA:
undetectable		 1s14A-2eryA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		5 / 11 LEU A  17
ILE A 123
PHE A 168
ALA A 167
LEU A  30
 None
 1.29A 2v0mD-2eryA:
undetectable		 2v0mD-2eryA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 8 LEU A 124
GLY A 142
TYR A 153
TYR A 105
 None
 0.73A 3af0A-2eryA:
2.3		 3af0A-2eryA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		5 / 12 ASP A 118
GLU A 119
MET A 122
PRO A 121
ILE A 111
 None
 1.46A 3lpsA-2eryA:
undetectable		 3lpsA-2eryA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		3 / 3 GLU A  48
LEU A  67
LEU A  30
 None
 0.78A 3ohtA-2eryA:
undetectable		 3ohtA-2eryA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		3 / 3 GLU A  48
LEU A  67
LEU A  91
 None
 0.75A 3ohtA-2eryA:
undetectable		 3ohtA-2eryA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		3 / 3 GLU A  48
LEU A  67
LEU A  91
 None
 0.73A 3ohtB-2eryA:
undetectable		 3ohtB-2eryA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 8 LEU A  30
VAL A 164
ASP A 130
ILE A 160
 None
None
GDP  A   1 (-3.0A)
None
 0.96A 4l4cB-2eryA:
undetectable		 4l4cB-2eryA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		5 / 11 ILE A  66
LEU A  90
HIS A 169
LEU A 171
ALA A 167
 None
 1.12A 4p65E-2eryA:
undetectable
4p65F-2eryA:
undetectable
4p65J-2eryA:
undetectable
4p65L-2eryA:
undetectable		 4p65E-2eryA:
9.52
4p65F-2eryA:
10.81
4p65J-2eryA:
10.81
4p65L-2eryA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 4 ILE A 175
ARG A  60
TYR A  15
GLU A  13
 None
 1.18A 4zzbD-2eryA:
undetectable		 4zzbD-2eryA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 5 ILE A 175
ARG A  60
TYR A  15
GLU A  13
 None
 1.21A 4zzcE-2eryA:
undetectable		 4zzcE-2eryA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		5 / 12 GLU A  87
GLY A  86
ILE A 111
VAL A  18
VAL A  20
 None
 1.14A 5dpdA-2eryA:
undetectable		 5dpdA-2eryA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 8 GLY A 126
ILE A 104
GLN A 148
ASP A  97
 None
 0.88A 5vlmH-2eryA:
undetectable		 5vlmH-2eryA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 4 ILE A  66
LEU A  90
HIS A 169
ALA A 167
 None
 0.99A 6ck2C-2eryA:
undetectable
6ck2D-2eryA:
undetectable		 6ck2C-2eryA:
9.52
6ck2D-2eryA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 5 ARG A 147
ALA A 146
TYR A 153
GLN A 144
 None
 1.12A 6f6sA-2eryA:
undetectable
6f6sB-2eryA:
undetectable		 6f6sA-2eryA:
17.75
6f6sB-2eryA:
21.47