SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2es3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 8 THR A 109
THR A  82
GLY A  84
ASP A 188
 None
 1.00A 1bu5B-2es3A:
undetectable		 1bu5B-2es3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		5 / 12 VAL A 142
LEU A 161
GLY A  69
SER A 167
PHE A  70
 None
 1.43A 1fdsA-2es3A:
undetectable		 1fdsA-2es3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		3 / 3 LEU A  89
LEU A  72
PHE A  57
 None
 0.60A 2pgrA-2es3A:
undetectable		 2pgrA-2es3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 8 LEU A 179
LEU A 114
VAL A 142
GLY A  69
 None
 0.95A 2po5B-2es3A:
undetectable		 2po5B-2es3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		5 / 11 LEU A  30
ARG A  29
LYS A  24
GLY A  25
SER A  26
 None
 1.39A 3bpxA-2es3A:
undetectable
3bpxB-2es3A:
undetectable		 3bpxA-2es3A:
21.00
3bpxB-2es3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 8 ALA A 107
GLY A 108
THR A 109
GLU A 126
 None
 0.93A 3rglA-2es3A:
undetectable		 3rglA-2es3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 8 PHE A 169
ALA A 177
PHE A  99
ALA A  88
 None
 0.89A 3t3sD-2es3A:
undetectable		 3t3sD-2es3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 8 PHE A 169
ALA A 177
PHE A  99
ALA A  88
 None
 0.99A 3t3sE-2es3A:
undetectable		 3t3sE-2es3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 8 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 1.00A 4d33A-2es3A:
undetectable		 4d33A-2es3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 7 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 1.02A 4d33B-2es3A:
undetectable		 4d33B-2es3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 7 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.97A 5b1bP-2es3A:
undetectable
5b1bW-2es3A:
undetectable		 5b1bP-2es3A:
19.34
5b1bW-2es3A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 6 GLY A  84
ASP A 188
ARG A  83
GLY A 105
 None
 0.89A 5cdnR-2es3A:
undetectable
5cdnS-2es3A:
undetectable		 5cdnR-2es3A:
19.38
5cdnS-2es3A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 7 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.92A 5z85C-2es3A:
undetectable
5z85J-2es3A:
undetectable		 5z85C-2es3A:
19.34
5z85J-2es3A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		4 / 7 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.94A 5zcqP-2es3A:
undetectable
5zcqW-2es3A:
undetectable		 5zcqP-2es3A:
19.34
5zcqW-2es3A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2es3 THROMBOSPONDIN-1
(Homo
sapiens) 		3 / 3 LEU A 130
ASN A 158
LEU A 112
 None
 0.70A 6exiA-2es3A:
undetectable		 6exiA-2es3A:
18.36