SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2es4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		3 / 3 LEU D  59
PRO D  60
LEU D  63
 None
 0.53A 1hrkA-2es4D:
undetectable		 1hrkA-2es4D:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		5 / 12 LEU D 116
ILE D 112
VAL D 128
GLY D 127
LEU D  79
 None
 1.27A 2bxeB-2es4D:
undetectable		 2bxeB-2es4D:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		5 / 12 PRO D 179
ASP D  90
LEU D  71
PRO D  72
GLU D 124
 None
 1.36A 2c7vC-2es4D:
undetectable		 2c7vC-2es4D:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 6 PHE D 180
ASP D  90
TYR D 132
PRO D 179
 None
 1.23A 3jqaA-2es4D:
undetectable		 3jqaA-2es4D:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 6 PHE D 180
ASP D  90
TYR D 132
PRO D 179
 None
 1.27A 3jqaB-2es4D:
undetectable		 3jqaB-2es4D:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 6 PHE D 180
ASP D  90
TYR D 132
PRO D 179
 None
 1.19A 3jqaC-2es4D:
undetectable		 3jqaC-2es4D:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 6 PHE D 180
ASP D  90
TYR D 132
PRO D 179
 None
 1.19A 3jqaD-2es4D:
undetectable		 3jqaD-2es4D:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 7 LEU D 139
TYR D 135
GLN D  96
LEU D  93
 None
None
None
CSO  D  92 ( 4.3A)
 0.96A 3qeoB-2es4D:
undetectable		 3qeoB-2es4D:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 4 ALA D 225
ALA D 228
ALA D 229
ALA D 232
 None
 0.13A 4oadA-2es4D:
undetectable		 4oadA-2es4D:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		4 / 4 ALA D 225
ALA D 228
ALA D 229
ALA D 232
 None
 0.12A 4oaeA-2es4D:
undetectable		 4oaeA-2es4D:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		5 / 11 PRO D  72
LEU D  79
VAL D 128
GLY D 127
LEU D 116
 None
 1.39A 5hbmA-2es4D:
2.3		 5hbmA-2es4D:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		5 / 12 ALA D 113
LEU D 107
TYR D 132
ASP D  90
PHE D  89
 None
CSO  D  92 ( 4.4A)
None
None
None
 1.46A 5vlmD-2es4D:
1.6		 5vlmD-2es4D:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		5 / 12 ALA D 114
LEU D 107
TYR D 132
ASP D  90
PHE D  89
 None
CSO  D  92 ( 4.4A)
None
None
None
 1.49A 5vlmD-2es4D:
1.6		 5vlmD-2es4D:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		3 / 3 ARG D  86
ARG D 165
ARG D 187
 None
 1.08A 6bplA-2es4D:
undetectable
6bplB-2es4D:
3.4		 6bplA-2es4D:
12.73
6bplB-2es4D:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2es4 LIPASE CHAPERONE
(Burkholderia
glumae) 		3 / 3 ARG D 311
ARG D 290
ASP D 328
 None
 0.95A 6d8pA-2es4D:
undetectable		 6d8pA-2es4D:
18.96