SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2esf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 8 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 300 (-3.3A)
None
 0.88A 1ekjA-2esfA:
21.3
1ekjB-2esfA:
20.7		 1ekjA-2esfA:
27.73
1ekjB-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 8 CYH A  42
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
None
 0.16A 1ekjA-2esfA:
21.3
1ekjB-2esfA:
20.7		 1ekjA-2esfA:
27.73
1ekjB-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 8 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 300 (-3.3A)
None
 0.96A 1ekjA-2esfA:
21.3
1ekjB-2esfA:
20.7		 1ekjA-2esfA:
27.73
1ekjB-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 8 CYH A  42
HIS A  98
CYH A 101
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
 0.99A 1ekjA-2esfA:
21.3
1ekjB-2esfA:
20.7		 1ekjA-2esfA:
27.73
1ekjB-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 8 CYH A  42
VAL A  66
HIS A  98
CYH A 101
GLY A 102
 ZN  A 300 (-2.3A)
None
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
 0.31A 1ekjA-2esfA:
21.3
1ekjB-2esfA:
20.7		 1ekjA-2esfA:
27.73
1ekjB-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 7 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 300 (-3.3A)
None
 0.87A 1ekjE-2esfA:
20.9
1ekjF-2esfA:
20.9		 1ekjE-2esfA:
27.73
1ekjF-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 7 CYH A  42
HIS A  98
GLY A 102
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.3A)
None
None
 0.22A 1ekjE-2esfA:
20.9
1ekjF-2esfA:
20.9		 1ekjE-2esfA:
27.73
1ekjF-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 8 CYH A  42
VAL A  66
GLY A 102
GLY A 103
 ZN  A 300 (-2.3A)
None
None
None
 0.17A 1ekjE-2esfA:
20.9
1ekjF-2esfA:
20.9		 1ekjE-2esfA:
27.73
1ekjF-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
 0.98A 1ekjG-2esfA:
20.9
1ekjH-2esfA:
21.1		 1ekjG-2esfA:
27.73
1ekjH-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 8 CYH A  42
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
None
 0.17A 1ekjG-2esfA:
20.9
1ekjH-2esfA:
21.1		 1ekjG-2esfA:
27.73
1ekjH-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 6 CYH A  42
VAL A  66
HIS A  98
CYH A 101
 ZN  A 300 (-2.3A)
None
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
 0.20A 1ekjG-2esfA:
20.9
1ekjH-2esfA:
21.1		 1ekjG-2esfA:
27.73
1ekjH-2esfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 11 LEU A  78
VAL A  70
ILE A  93
ILE A 176
VAL A  85
 None
 1.41A 1gx9A-2esfA:
undetectable		 1gx9A-2esfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 6 LEU A 212
LEU A 134
GLU A 153
MET A 152
 None
 1.16A 2kuhA-2esfA:
undetectable		 2kuhA-2esfA:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		6 / 10 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
ALA A 107
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
None
 1.17A 3ucjA-2esfA:
26.4		 3ucjA-2esfA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
ALA A 107
 ZN  A 300 (-2.3A)
None
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
 0.92A 3ucjA-2esfA:
26.4		 3ucjA-2esfA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		6 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 300 (-2.3A)
None
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
None
 0.26A 3ucjA-2esfA:
26.4		 3ucjA-2esfA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		6 / 10 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
ALA A 107
 ZN  A 300 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
None
 1.19A 3ucjB-2esfA:
27.1		 3ucjB-2esfA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		5 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
ALA A 107
 ZN  A 300 (-2.3A)
None
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
 0.91A 3ucjB-2esfA:
27.1		 3ucjB-2esfA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		6 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 300 (-2.3A)
None
ZN  A 300 (-3.3A)
ZN  A 300 (-2.3A)
None
None
 0.29A 3ucjB-2esfA:
27.1		 3ucjB-2esfA:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 7 GLU A 148
TYR A  99
HIS A 184
VAL A  47
 None
 1.07A 4a97D-2esfA:
undetectable		 4a97D-2esfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 6 GLU A 148
TYR A  99
HIS A 184
VAL A  47
 None
 1.07A 4a97E-2esfA:
undetectable		 4a97E-2esfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 8 VAL A 155
CYH A  77
ILE A 176
ILE A  40
 None
 0.71A 4afgD-2esfA:
undetectable
4afgE-2esfA:
undetectable		 4afgD-2esfA:
21.86
4afgE-2esfA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 6 LEU A 134
LYS A 129
LEU A 149
GLU A 153
 None
 1.02A 4f3tA-2esfA:
3.4		 4f3tA-2esfA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 7 LEU A 134
LYS A 129
LEU A 149
GLU A 153
 None
 1.06A 4z4fA-2esfA:
3.6		 4z4fA-2esfA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		4 / 7 LEU A 134
LYS A 129
LEU A 149
GLU A 153
 None
 1.06A 5t7bA-2esfA:
undetectable		 5t7bA-2esfA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2esf CARBONIC ANHYDRASE 2
(Escherichia
coli) 		3 / 3 ARG A 142
GLY A 135
GLU A 136
 None
 0.39A 6fgdA-2esfA:
undetectable		 6fgdA-2esfA:
20.19