SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2esn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 250
LEU A 247
LEU A 248
LEU A 238
ALA A 241
 None
 1.31A 1e7cA-2esnA:
undetectable		 1e7cA-2esnA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 155
THR A 106
TYR A 108
TRP A 171
 None
 1.44A 1eiiA-2esnA:
undetectable		 1eiiA-2esnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  88
TRP A  89
LYS A 300
 None
 1.19A 1qu2A-2esnA:
undetectable		 1qu2A-2esnA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  94
SER A  97
PHE A 101
TRP A 294
 None
 0.31A 2y7kA-2esnA:
16.0		 2y7kA-2esnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 153
VAL A 141
LEU A 139
LEU A 280
LEU A 299
 None
 1.01A 3cjtC-2esnA:
undetectable		 3cjtC-2esnA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 101
PHE A 151
PHE A 103
GLY A 297
LEU A 117
 None
 1.04A 3t3rA-2esnA:
undetectable		 3t3rA-2esnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 153
PHE A 151
PHE A 103
LEU A 113
 None
 1.07A 3wg7C-2esnA:
undetectable
3wg7J-2esnA:
undetectable		 3wg7C-2esnA:
23.96
3wg7J-2esnA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 180
ALA A 241
ALA A 262
ALA A 259
ALA A 265
 None
 1.44A 4twdF-2esnA:
undetectable
4twdG-2esnA:
undetectable
4twdH-2esnA:
undetectable
4twdI-2esnA:
undetectable
4twdJ-2esnA:
undetectable		 4twdF-2esnA:
21.76
4twdG-2esnA:
21.76
4twdH-2esnA:
21.76
4twdI-2esnA:
21.76
4twdJ-2esnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 299
LEU A 280
LEU A 130
LEU A 117
 None
 0.73A 5jqbA-2esnA:
undetectable
5jqbB-2esnA:
undetectable		 5jqbA-2esnA:
21.61
5jqbB-2esnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 ARG A 182
ALA A 265
LEU A 264
GLY A 242
LEU A 278
 None
 1.25A 5oy01-2esnA:
undetectable
5oy07-2esnA:
undetectable		 5oy01-2esnA:
12.93
5oy07-2esnA:
9.70