SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2esp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		5 / 12 PRO A  65
THR A  53
VAL A  67
LEU A  86
ILE A 106
 None
 1.47A 2fj1A-2espA:
undetectable		 2fj1A-2espA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		4 / 7 PRO A  44
TYR A  74
HIS A  75
PRO A  76
 None
 1.18A 2ombC-2espA:
undetectable
2ombD-2espA:
undetectable		 2ombC-2espA:
19.74
2ombD-2espA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		4 / 7 TYR A  74
HIS A  75
PRO A  76
PRO A  44
 None
 1.09A 2ombC-2espA:
undetectable
2ombD-2espA:
undetectable		 2ombC-2espA:
19.74
2ombD-2espA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		5 / 11 ILE A  99
LEU A  86
LEU A 103
ILE A 106
PRO A  65
 None
 1.13A 3a50B-2espA:
undetectable		 3a50B-2espA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		5 / 11 ILE A  99
LEU A 103
ILE A 106
PRO A  65
LEU A  89
 None
 1.15A 3a51A-2espA:
undetectable		 3a51A-2espA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		5 / 12 ILE A  99
LEU A 103
ILE A 106
PRO A  65
LEU A  89
 None
 1.16A 3a51D-2espA:
undetectable		 3a51D-2espA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		5 / 12 THR A 142
VAL A 120
LEU A 119
ILE A 123
TYR A 134
 None
 1.39A 3elzC-2espA:
undetectable		 3elzC-2espA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		5 / 11 ILE A 106
ILE A  99
ILE A  37
ALA A  23
VAL A  67
 None
 1.02A 4h1nA-2espA:
undetectable		 4h1nA-2espA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		4 / 5 SER A 100
LYS A 101
LEU A  13
ASP A  12
 None
 1.32A 4ifxA-2espA:
undetectable		 4ifxA-2espA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		4 / 5 SER A 100
LYS A 101
LEU A  13
ASP A  12
 None
 1.33A 4ig1A-2espA:
undetectable		 4ig1A-2espA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		4 / 5 SER A 100
LYS A 101
LEU A  13
ASP A  12
 None
 1.33A 4xdtA-2espA:
1.3		 4xdtA-2espA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens) 		3 / 3 ILE A  84
VAL A  67
PRO A  65
 None
 0.69A 5uunA-2espA:
undetectable		 5uunA-2espA:
17.18