SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2esr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 117
PHE A  49
GLY A  51
SER A  52
ASN A  73
 None
 0.90A 1g60A-2esrA:
5.2		 1g60A-2esrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  32
PHE A 115
ALA A  59
ILE A  80
ASN A  83
 None
 1.16A 2rlcA-2esrA:
undetectable		 2rlcA-2esrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		4 / 4 LYS A 135
LEU A 137
ALA A 134
LEU A 138
 None
 1.39A 2roxA-2esrA:
undetectable		 2roxA-2esrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 100
PRO A 118
PHE A  49
GLY A  51
GLU A  71
 None
 1.11A 2zifA-2esrA:
4.4		 2zifA-2esrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 100
PRO A 119
PHE A  49
GLY A  51
GLU A  71
 None
 0.64A 2zifA-2esrA:
4.4		 2zifA-2esrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 PHE A  49
GLY A  51
ASN A  73
ASP A 117
PRO A 119
 None
 0.85A 4rtpA-2esrA:
11.0		 4rtpA-2esrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 PHE A  49
GLY A  51
ASN A  73
ASP A 117
PRO A 119
 None
 0.88A 4rtsA-2esrA:
10.9		 4rtsA-2esrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		6 / 12 GLY A  51
GLY A  53
GLY A  54
LEU A  55
GLU A  71
ASP A 117
 None
 1.31A 5c0oF-2esrA:
14.1		 5c0oF-2esrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  53
GLY A  54
LEU A  55
ALA A 100
ASP A 117
 None
 0.92A 5c0oF-2esrA:
14.1		 5c0oF-2esrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		6 / 12 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
GLU A  71
 None
 0.71A 5hfjA-2esrA:
3.6		 5hfjA-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		6 / 12 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
SER A  52
 None
 0.81A 5hfjB-2esrA:
3.8		 5hfjB-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		7 / 12 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
SER A  52
GLU A  71
 None
 0.82A 5hfjD-2esrA:
4.4		 5hfjD-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		6 / 12 ALA A 100
ASP A 117
PHE A  49
GLY A  51
SER A  52
GLU A  71
 None
 0.74A 5hfjE-2esrA:
3.6		 5hfjE-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		7 / 12 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
SER A  52
GLU A  71
 None
 0.79A 5hfjF-2esrA:
4.4		 5hfjF-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
 None
 0.77A 5hfjG-2esrA:
3.5		 5hfjG-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 100
ASP A 117
PRO A 119
PHE A  49
GLY A  51
 None
 0.74A 5hfjH-2esrA:
4.5		 5hfjH-2esrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		5 / 11 PHE A  49
GLY A  51
GLU A  71
ASN A  73
PRO A 119
 None
 0.67A 5hjiA-2esrA:
13.5		 5hjiA-2esrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		4 / 4 LYS A 135
LEU A 137
ALA A 134
LEU A 138
 None
 1.38A 6gnrA-2esrA:
undetectable		 6gnrA-2esrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2esr METHYLTRANSFERASE
(Streptococcus
pyogenes) 		4 / 4 LYS A 135
LEU A 137
ALA A 134
LEU A 138
 None
 1.37A 6gnrB-2esrA:
undetectable		 6gnrB-2esrA:
20.22