SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2esw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_B_SAMB1267_0 (NON-STRUCTURAL PROTEIN 5)	2esw	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 (Mus musculus)	5 / 12	GLY A 40 GLY A 44 TRP A 42 GLU A 22 ILE A 31	None	0.91A	2wa2B-2eswA: undetectable	2wa2B-2eswA: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_D_SAMD301_0 (NS5)	2esw	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 (Mus musculus)	5 / 12	GLY A 40 GLY A 44 TRP A 42 GLU A 22 ILE A 31	None	0.90A	5njvD-2eswA: undetectable	5njvD-2eswA: 14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_D_SAMD601_0 (NS5 METHYLTRANSFERASE)	2esw	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 (Mus musculus)	5 / 12	GLY A 40 GLY A 44 TRP A 42 GLU A 22 ILE A 31	None	1.05A	5wz1D-2eswA: undetectable	5wz1D-2eswA: 12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_F_SAMF601_0 (NS5 METHYLTRANSFERASE)	2esw	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 (Mus musculus)	5 / 12	GLY A 40 GLY A 44 TRP A 42 GLU A 22 ILE A 31	None	1.05A	5wz1F-2eswA: undetectable	5wz1F-2eswA: 12.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WA2_B_SAMB1267_0","NON-STRUCTURAL PROTEIN 5","2esw","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7","Mus musculus",5,"GLY A  40;GLY A  44;TRP A  42;GLU A  22;ILE A  31","None","0.91A","2wa2B-2eswA:undetectable","2wa2B-2eswA:17.22"],["5NJV_D_SAMD301_0","NS5","2esw","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7","Mus musculus",5,"GLY A  40;GLY A  44;TRP A  42;GLU A  22;ILE A  31","None","0.90A","5njvD-2eswA:undetectable","5njvD-2eswA:14.06"],["5WZ1_D_SAMD601_0","NS5 METHYLTRANSFERASE","2esw","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7","Mus musculus",5,"GLY A  40;GLY A  44;TRP A  42;GLU A  22;ILE A  31","None","1.05A","5wz1D-2eswA:undetectable","5wz1D-2eswA:12.59"],["5WZ1_F_SAMF601_0","NS5 METHYLTRANSFERASE","2esw","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7","Mus musculus",5,"GLY A  40;GLY A  44;TRP A  42;GLU A  22;ILE A  31","None","1.05A","5wz1F-2eswA:undetectable","5wz1F-2eswA:12.59"]]