SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		4 / 6 ALA A 167
LEU A 140
ASP A 143
LEU A 106
 None
 0.87A 1mt1D-2etaA:
undetectable
1mt1E-2etaA:
undetectable		 1mt1D-2etaA:
17.72
1mt1E-2etaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		5 / 9 GLY A 278
LEU A 275
TYR A 271
LEU A 253
THR A 248
 None
 1.05A 2npnA-2etaA:
undetectable		 2npnA-2etaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		4 / 7 VAL A 184
VAL A 180
LEU A 177
SER A 176
 None
 0.71A 3hs6B-2etaA:
undetectable		 3hs6B-2etaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		4 / 7 VAL A 153
VAL A 190
ASN A 186
GLY A 187
 None
 1.09A 3kmoB-2etaA:
undetectable		 3kmoB-2etaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		4 / 8 ASN A 259
ASN A 263
ILE A 256
LYS A 307
 None
 1.29A 3kp6A-2etaA:
undetectable
3kp6B-2etaA:
undetectable		 3kp6A-2etaA:
20.63
3kp6B-2etaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		3 / 3 CYH A 179
ASN A 133
LYS A 174
 None
 1.33A 4k50A-2etaA:
undetectable		 4k50A-2etaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		3 / 3 SER A 146
ASP A  78
ASP A 108
 None
 0.79A 4uckA-2etaA:
undetectable		 4uckA-2etaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Rattus
norvegicus) 		4 / 6 ALA A 188
GLN A 235
LEU A 183
LEU A 229
 None
 1.09A 4xoyA-2etaA:
undetectable		 4xoyA-2etaA:
20.39