SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2etv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 SER A  89
VAL A  90
GLY A  91
GLY A  63
TYR A 288
None
0.88A 1fduA-2etvA:
undetectable
1fduA-2etvA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 SER A  89
VAL A  90
GLY A  91
GLY A  63
TYR A 288
None
0.98A 1fduC-2etvA:
undetectable
1fduC-2etvA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 GLY A 303
LEU A 218
PRO A 190
VAL A 192
PHE A 248
None
1.04A 1gseA-2etvA:
undetectable
1gseA-2etvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
4 / 6 PRO A 214
ASP A 250
ASN A 252
TYR A 212
None
1.49A 1hpkA-2etvA:
undetectable
1hpkA-2etvA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
4 / 7 ILE A 302
PRO A 214
PHE A 144
ALA A 295
None
0.93A 1oniG-2etvA:
undetectable
1oniI-2etvA:
undetectable
1oniG-2etvA:
18.81
1oniI-2etvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 VAL A 111
ILE A  41
ILE A  52
VAL A 134
LEU A 136
None
1.03A 1qhyA-2etvA:
undetectable
1qhyA-2etvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 TYR A  54
THR A 115
GLY A  45
ILE A 292
VAL A 170
None
1.14A 1r30A-2etvA:
undetectable
1r30A-2etvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 TYR A  54
THR A 115
GLY A  45
ILE A 292
VAL A 170
None
1.14A 1r30B-2etvA:
undetectable
1r30B-2etvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
3 / 3 VAL A 223
VAL A 241
ASP A 260
None
MLY  A 238 (-3.8A)
EDO  A  13 (-2.9A)
0.65A 2fumD-2etvA:
undetectable
2fumD-2etvA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
4 / 5 TYR A 212
VAL A 194
ASP A 250
SER A 207
None
None
None
MLY  A 232 ( 4.6A)
1.28A 2x45A-2etvA:
undetectable
2x45A-2etvA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
4 / 5 TYR A 212
VAL A 194
ASP A 250
SER A 207
None
None
None
MLY  A 232 ( 4.6A)
1.26A 2x45C-2etvA:
undetectable
2x45C-2etvA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
3 / 3 GLY A 204
GLY A 198
GLY A 196
EDO  A  16 (-4.0A)
None
None
0.39A 3bogC-2etvA:
undetectable
3bogC-2etvA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 SER A 270
ILE A 205
LEU A 348
VAL A 274
PRO A 236
None
None
None
MLY  A 275 ( 3.0A)
EDO  A  13 (-4.5A)
1.26A 3dcjA-2etvA:
3.1
3dcjB-2etvA:
3.1
3dcjA-2etvA:
22.90
3dcjB-2etvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 GLY A  91
GLY A  45
GLY A  93
THR A 115
LEU A 136
None
None
MLY  A  97 ( 4.2A)
None
None
1.09A 3eluA-2etvA:
undetectable
3eluA-2etvA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
3 / 3 ASP A 321
ARG A 331
ARG A 355
None
1.00A 3k37A-2etvA:
undetectable
3k37A-2etvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
3 / 3 TYR A 333
ASP A 315
ASP A 313
None
None
EDO  A   5 (-3.9A)
0.94A 3ou6B-2etvA:
undetectable
3ou6B-2etvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
3 / 3 THR A 294
ASP A 250
GLU A 209
None
0.85A 3qowA-2etvA:
undetectable
3qowA-2etvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 11 GLY A  74
TYR A 287
ALA A  53
ASN A 291
TYR A  54
None
EDO  A  19 (-3.6A)
None
None
None
1.32A 3qxyB-2etvA:
undetectable
3qxyQ-2etvA:
undetectable
3qxyB-2etvA:
22.83
3qxyQ-2etvA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
4 / 8 ASP A 298
ALA A 297
TYR A 333
TYR A 324
None
1.06A 3rodA-2etvA:
undetectable
3rodA-2etvA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 ALA A  48
ILE A 159
LEU A  27
VAL A 134
ILE A  34
None
MLY  A 158 (-4.3A)
None
None
None
1.13A 4aztA-2etvA:
undetectable
4aztA-2etvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 PHE A 113
ARG A 162
VAL A 170
LEU A  55
LEU A 136
None
MLY  A  56 ( 3.9A)
None
MLY  A  56 ( 4.6A)
None
1.36A 4qzuA-2etvA:
undetectable
4qzuA-2etvA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 ALA A  48
ILE A 159
LEU A  27
VAL A 134
ILE A  34
None
MLY  A 158 (-4.3A)
None
None
None
1.08A 4uw0A-2etvA:
undetectable
4uw0A-2etvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
4 / 7 TYR A 116
GLY A 139
SER A 137
LEU A 149
EDO  A  21 ( 4.0A)
None
None
None
1.19A 5bphB-2etvA:
2.4
5bphB-2etvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
3 / 3 THR A 294
ASP A 250
GLU A 209
None
0.68A 5fa8A-2etvA:
undetectable
5fa8A-2etvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 10 TYR A 268
ASP A 260
VAL A 279
ILE A 346
ILE A 234
None
EDO  A  13 (-2.9A)
MLY  A 278 ( 3.1A)
MLY  A 345 ( 4.2A)
None
1.18A 5hw8C-2etvA:
undetectable
5hw8H-2etvA:
undetectable
5hw8C-2etvA:
20.06
5hw8H-2etvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 LEU A 271
ILE A 205
GLY A 195
ILE A 249
TYR A 212
None
1.09A 5ifuA-2etvA:
undetectable
5ifuA-2etvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 12 TYR A 193
TYR A 268
LEU A 348
ILE A 249
GLY A 195
None
1.22A 5ifuA-2etvA:
undetectable
5ifuA-2etvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 9 TYR A 193
TYR A 268
LEU A 348
ILE A 249
GLY A 195
None
1.28A 5ifuB-2etvA:
undetectable
5ifuB-2etvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 10 GLY A  74
TYR A 287
TYR A 288
ASN A 291
TYR A  54
None
EDO  A  19 (-3.6A)
None
None
None
1.25A 5tqrB-2etvA:
0.0
5tqrB-2etvA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima)
5 / 11 ASP A 298
PHE A 301
ILE A 302
ILE A 353
TYR A 333
None
None
None
MLY  A 345 ( 4.1A)
None
1.09A 6fgdA-2etvA:
2.2
6fgdA-2etvA:
15.48