SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		3 / 3 VAL A  36
VAL A  49
TRP A  11
 None
 0.94A 1av2C-2eu0A:
undetectable
1av2D-2eu0A:
undetectable		 1av2C-2eu0A:
4.59
1av2D-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		3 / 3 VAL A  36
VAL A  49
TRP A  11
 None
 0.92A 1w5uC-2eu0A:
undetectable
1w5uD-2eu0A:
undetectable		 1w5uC-2eu0A:
4.59
1w5uD-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		3 / 3 VAL A  49
TRP A  11
VAL A  36
 None
 0.89A 2izqA-2eu0A:
undetectable
2izqB-2eu0A:
undetectable		 2izqA-2eu0A:
4.59
2izqB-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		5 / 10 ALA A  79
GLN A  92
LEU A  89
ASN A  97
LEU A  90
 None
 1.15A 2riwA-2eu0A:
undetectable
2riwB-2eu0A:
undetectable		 2riwA-2eu0A:
17.54
2riwB-2eu0A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		4 / 7 ILE A  91
LEU A  90
THR A 103
LEU A 101
 None
 0.93A 3ag3A-2eu0A:
undetectable
3ag3J-2eu0A:
undetectable		 3ag3A-2eu0A:
11.27
3ag3J-2eu0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		3 / 3 VAL A  36
VAL A  49
TRP A  11
 None
 0.70A 3l8lA-2eu0A:
undetectable
3l8lB-2eu0A:
undetectable		 3l8lA-2eu0A:
4.59
3l8lB-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		3 / 3 VAL A  36
VAL A  49
TRP A  11
 None
 0.81A 3l8lC-2eu0A:
undetectable
3l8lD-2eu0A:
undetectable		 3l8lC-2eu0A:
4.59
3l8lD-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		5 / 9 ALA A  79
GLN A  92
LEU A  89
ASN A  97
LEU A  90
 None
 1.10A 4x30A-2eu0A:
undetectable		 4x30A-2eu0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		4 / 7 ILE A  91
LEU A  90
THR A 103
LEU A 101
 None
 0.97A 5b3sA-2eu0A:
undetectable
5b3sJ-2eu0A:
undetectable		 5b3sA-2eu0A:
11.27
5b3sJ-2eu0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		3 / 3 ASP A  38
ASN A  13
PHE A  34
 None
 0.77A 5dsgB-2eu0A:
undetectable		 5dsgB-2eu0A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		4 / 7 ILE A  91
LEU A  90
THR A 103
LEU A 101
 None
 0.96A 5xdqN-2eu0A:
undetectable
5xdqW-2eu0A:
undetectable		 5xdqN-2eu0A:
11.27
5xdqW-2eu0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		4 / 7 ILE A  91
LEU A  90
THR A 103
LEU A 101
 None
 0.93A 5xdxA-2eu0A:
undetectable
5xdxJ-2eu0A:
undetectable		 5xdxA-2eu0A:
11.27
5xdxJ-2eu0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		5 / 12 LEU A 101
VAL A  49
GLU A  68
THR A  41
GLY A  43
 None
 1.34A 5xiqD-2eu0A:
undetectable		 5xiqD-2eu0A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		4 / 7 ILE A  91
LEU A  90
THR A 103
LEU A 101
 None
 0.96A 5zcpA-2eu0A:
undetectable
5zcpJ-2eu0A:
undetectable		 5zcpA-2eu0A:
11.27
5zcpJ-2eu0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK
(Mus
musculus) 		5 / 12 LEU A 101
VAL A  49
GLU A  68
THR A  41
GLY A  43
 None
 1.29A 6mn8A-2eu0A:
undetectable		 6mn8A-2eu0A:
13.83