SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ew1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 ILE A  11
ALA A 166
PHE A 162
LEU A  24
ILE A  85
 None
 1.04A 1cd2A-2ew1A:
undetectable		 1cd2A-2ew1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 ILE A  11
ALA A 166
PHE A 162
LEU A  24
ILE A  85
 None
 1.07A 1rb2B-2ew1A:
undetectable		 1rb2B-2ew1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A 701 ( 3.0A)
GNP  A 700 (-3.1A)
GNP  A 700 (-3.6A)
GNP  A 700 (-3.0A)
GNP  A 700 (-3.0A)
 1.06A 2b25A-2ew1A:
2.6		 2b25A-2ew1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		3 / 3 ASP A 156
ASN A 157
THR A  87
 None
 0.74A 2pymB-2ew1A:
undetectable		 2pymB-2ew1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		3 / 3 GLY A  18
GLY A  20
THR A  22
 GNP  A 700 (-3.6A)
GNP  A 700 (-3.1A)
MG  A 701 ( 3.0A)
 0.45A 3si7B-2ew1A:
undetectable		 3si7B-2ew1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 ILE A  11
ALA A 166
PHE A 162
LEU A  24
ILE A  85
 None
 1.02A 4kjkA-2ew1A:
undetectable		 4kjkA-2ew1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 ILE A  11
ALA A 166
PHE A 162
LEU A  24
ILE A  85
 None
 1.03A 4km2B-2ew1A:
undetectable		 4km2B-2ew1A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		4 / 7 GLU A 149
THR A 150
THR A 116
LEU A  99
 None
 1.06A 4pfjA-2ew1A:
3.7		 4pfjA-2ew1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		4 / 8 ILE A  61
LEU A  59
ILE A  11
ILE A  85
 None
 0.70A 5numA-2ew1A:
undetectable		 5numA-2ew1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		4 / 7 TYR A  77
VAL A 117
ILE A 106
GLY A  42
 None
 0.82A 6hd6B-2ew1A:
undetectable		 6hd6B-2ew1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 ILE A  11
ALA A 166
PHE A 162
LEU A  24
ILE A  85
 None
 1.02A 7dfrA-2ew1A:
undetectable		 7dfrA-2ew1A:
22.33