SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ew2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		3 / 3 PHE A 168
LEU A 102
LEU A 104
 None
 0.67A 1mx1E-2ew2A:
1.6		 1mx1E-2ew2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 12 ARG A 139
GLY A   9
ALA A   8
ILE A  36
ALA A  38
 None
 1.05A 1sguB-2ew2A:
undetectable		 1sguB-2ew2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 10 GLY A 172
ALA A 171
ILE A   3
GLY A  16
ILE A  17
 None
 0.94A 1t3rA-2ew2A:
undetectable		 1t3rA-2ew2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 10 GLY A 172
ALA A 171
ILE A   3
GLY A  16
ILE A  17
 None
 0.96A 1t7iA-2ew2A:
undetectable		 1t7iA-2ew2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 12 ALA A  10
GLY A  12
MET A  18
GLY A 172
LEU A 173
 None
 1.03A 2hw2A-2ew2A:
undetectable		 2hw2A-2ew2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 8 LEU A  78
ILE A   5
LEU A  15
THR A 128
LEU A 104
 None
 1.35A 2xfhA-2ew2A:
undetectable		 2xfhA-2ew2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 12 LEU A 150
GLY A 109
LEU A 102
VAL A 101
ILE A 123
 None
 0.89A 3adxB-2ew2A:
undetectable		 3adxB-2ew2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 10 THR A 128
GLY A 126
PHE A 168
GLU A 149
ILE A  76
 None
 1.15A 3kvrB-2ew2A:
undetectable		 3kvrB-2ew2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 10 THR A 128
PHE A 168
GLU A 149
LEU A 104
ILE A  76
 None
 1.28A 3kvrB-2ew2A:
undetectable		 3kvrB-2ew2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 10 GLY A 172
ALA A 171
ILE A   3
GLY A  16
ILE A  17
 None
 0.94A 3lzvA-2ew2A:
undetectable		 3lzvA-2ew2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		3 / 3 PHE A 209
TYR A 243
TYR A 250
 None
 0.85A 4ffwA-2ew2A:
undetectable		 4ffwA-2ew2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		3 / 3 MET A   1
MET A  94
TYR A 100
 None
 1.04A 4p6xI-2ew2A:
undetectable		 4p6xI-2ew2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 11 GLY A 172
ALA A 171
ILE A   3
GLY A  16
ILE A  17
 None
 0.94A 4q1xA-2ew2A:
undetectable		 4q1xA-2ew2A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A  77
LEU A  74
THR A 128
ILE A 148
LEU A 173
 None
 1.43A 4x5gA-2ew2A:
undetectable		 4x5gA-2ew2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A  77
LEU A  74
THR A 128
ILE A 148
LEU A 173
 None
 1.42A 4x5gB-2ew2A:
undetectable		 4x5gB-2ew2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 7 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.83A 5a06A-2ew2A:
7.2		 5a06A-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 7 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.81A 5a06B-2ew2A:
7.2		 5a06B-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 7 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.83A 5a06C-2ew2A:
7.2		 5a06C-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 7 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.82A 5a06E-2ew2A:
7.2		 5a06E-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 7 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.85A 5a06F-2ew2A:
7.3		 5a06F-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 7 MET A 262
GLY A 280
ASN A 279
HIS A 304
 None
 1.33A 5a5zC-2ew2A:
undetectable		 5a5zC-2ew2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 5 VAL A 303
THR A 200
ASP A 265
LEU A 266
 None
 1.28A 5m0iB-2ew2A:
undetectable		 5m0iB-2ew2A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 12 VAL A 113
ASP A 112
ALA A  81
ARG A 284
GLY A 280
 None
 1.19A 5m54E-2ew2A:
undetectable		 5m54E-2ew2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 4 THR A 273
ASP A 265
ARG A 271
LEU A 266
 None
 1.01A 5tdmA-2ew2A:
0.0		 5tdmA-2ew2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		4 / 6 THR A 273
ASP A 265
ARG A 271
LEU A 266
 None
 1.03A 5tdzA-2ew2A:
3.6		 5tdzA-2ew2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 12 VAL A 140
LEU A 173
ALA A 132
GLY A   7
LEU A  78
 None
 1.04A 6b0iB-2ew2A:
undetectable		 6b0iB-2ew2A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE
(Enterococcus
faecalis) 		5 / 10 ALA A  10
LEU A 134
VAL A 140
ALA A  38
LEU A  44
 None
 1.34A 6h1lA-2ew2A:
undetectable		 6h1lA-2ew2A:
23.77