SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ew7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 8 ALA A 128
ILE A  84
PRO A  81
ILE A 140
ILE A 136
 None
 1.27A 1hshD-2ew7A:
undetectable		 1hshD-2ew7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 11 ASP A 141
ARG A 108
PHE A 148
VAL A  99
ILE A  50
 None
 1.09A 1tcoC-2ew7A:
undetectable		 1tcoC-2ew7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		3 / 3 HIS A 138
ILE A  61
LEU A 131
 CO  A 300 (-3.3A)
None
None
 0.60A 2kceA-2ew7A:
undetectable		 2kceA-2ew7A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 12 MET A  35
LEU A  47
GLY A  46
LEU A 143
ILE A  78
 None
 1.24A 3h52A-2ew7A:
undetectable		 3h52A-2ew7A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		3 / 3 HIS A 138
GLU A 139
HIS A 142
 CO  A 300 (-3.3A)
CO  A 300 ( 4.0A)
CO  A 300 (-3.3A)
 0.19A 3kecB-2ew7A:
undetectable		 3kecB-2ew7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 9 GLY A  44
GLN A  70
GLU A  43
LEU A  47
ILE A  60
 None
 1.33A 3nbqA-2ew7A:
undetectable		 3nbqA-2ew7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		4 / 8 ILE A  78
ILE A 140
GLU A  85
THR A  86
 None
 0.80A 3ua5A-2ew7A:
undetectable		 3ua5A-2ew7A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 10 ASP A 141
ARG A 108
PHE A 148
VAL A  99
ILE A  50
 None
 1.19A 3uqaA-2ew7A:
undetectable		 3uqaA-2ew7A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 10 ASP A 141
ARG A 108
PHE A 148
VAL A  99
ILE A  50
 None
 1.15A 4dz3B-2ew7A:
undetectable		 4dz3B-2ew7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 9 ALA A  48
ALA A 135
ILE A  45
GLY A  46
ILE A  61
 None
 1.13A 4eatB-2ew7A:
undetectable		 4eatB-2ew7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		5 / 12 GLY A  44
ILE A  60
ASN A  62
LEU A  63
PRO A  64
 None
 0.99A 4gc9A-2ew7A:
undetectable		 4gc9A-2ew7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2ew7 PEPTIDE DEFORMYLASE
(Helicobacter
pylori) 		3 / 3 HIS A 142
HIS A 138
ARG A 108
 CO  A 300 (-3.3A)
CO  A 300 (-3.3A)
None
 1.11A 6b58A-2ew7A:
undetectable		 6b58A-2ew7A:
17.00