SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ew9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 12 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 0.98A 1oipA-2ew9A:
undetectable		 1oipA-2ew9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 12 ILE A 108
ILE A  86
VAL A 113
VAL A 122
ILE A 134
 None
 1.25A 1r5lA-2ew9A:
undetectable		 1r5lA-2ew9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 12 GLY A 142
GLY A  88
MET A  89
ASP A 133
ILE A 134
 None
 1.15A 2b25B-2ew9A:
undetectable		 2b25B-2ew9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 11 ILE A 134
PRO A 131
LEU A 102
ILE A  98
THR A 117
 None
 0.98A 3clbA-2ew9A:
undetectable		 3clbA-2ew9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 12 ILE A 134
PRO A 131
LEU A 102
ILE A  98
THR A 117
 None
 1.04A 3clbC-2ew9A:
undetectable		 3clbC-2ew9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 9 ILE A 138
ILE A  86
ALA A 148
LEU A  84
LEU A 102
 None
 1.09A 3ozvB-2ew9A:
undetectable		 3ozvB-2ew9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		3 / 3 LYS A 119
LEU A 121
ALA A 114
 None
 0.60A 4iizA-2ew9A:
undetectable		 4iizA-2ew9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 12 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 0.99A 5mueA-2ew9A:
undetectable		 5mueA-2ew9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ew9 COPPER-TRANSPORTING
ATPASE 2
(Homo
sapiens) 		5 / 12 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 1.00A 5mugA-2ew9A:
undetectable		 5mugA-2ew9A:
19.11