SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ewc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OC8_A_HU5A999_1 (HEPATITIS C VIRUS)	2ewc	CONSERVED HYPOTHETICAL PROTEIN (Streptococcus pyogenes)	5 / 12	HIS A 122 LEU A 53 GLY A 57 ALA A 118 VAL A 117	None	0.95A	2oc8A-2ewcA: undetectable	2oc8A-2ewcA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H52_D_486D2_1 (GLUCOCORTICOID RECEPTOR)	2ewc	CONSERVED HYPOTHETICAL PROTEIN (Streptococcus pyogenes)	5 / 12	MET A 49 GLY A 32 VAL A 34 MET A 66 LEU A 69	None GOL A2001 ( 3.8A) GOL A2001 (-3.6A) None None	1.43A	3h52D-2ewcA: undetectable	3h52D-2ewcA: 15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	2ewc	CONSERVED HYPOTHETICAL PROTEIN (Streptococcus pyogenes)	4 / 6	PHE A 87 MET A 66 ILE A 83 ARG A 86	None	1.30A	4mk4B-2ewcA: undetectable	4mk4B-2ewcA: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U4S_A_BEZA301_0 (PUTATIVE SHORT CHAIN DEHYDROGENASE)	2ewc	CONSERVED HYPOTHETICAL PROTEIN (Streptococcus pyogenes)	4 / 7	LEU A 60 MET A 49 LEU A 53 PRO A 92	None	0.92A	5u4sA-2ewcA: undetectable	5u4sA-2ewcA: 21.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OC8_A_HU5A999_1","HEPATITIS C VIRUS","2ewc","CONSERVED HYPOTHETICAL PROTEIN","Streptococcus pyogenes",5,"HIS A 122;LEU A  53;GLY A  57;ALA A 118;VAL A 117","None","0.95A","2oc8A-2ewcA:undetectable","2oc8A-2ewcA:20.20"],["3H52_D_486D2_1","GLUCOCORTICOID RECEPTOR","2ewc","CONSERVED HYPOTHETICAL PROTEIN","Streptococcus pyogenes",5,"MET A  49;GLY A  32;VAL A  34;MET A  66;LEU A  69","None;GOL A2001 ( 3.8A);GOL A2001 (-3.6A);None;None","1.43A","3h52D-2ewcA:undetectable","3h52D-2ewcA:15.48"],["4MK4_B_CHDB502_0","FERROCHELATASE, MITOCHONDRIAL","2ewc","CONSERVED HYPOTHETICAL PROTEIN","Streptococcus pyogenes",4,"PHE A  87;MET A  66;ILE A  83;ARG A  86","None","1.30A","4mk4B-2ewcA:undetectable","4mk4B-2ewcA:15.86"],["5U4S_A_BEZA301_0","PUTATIVE SHORT CHAIN DEHYDROGENASE","2ewc","CONSERVED HYPOTHETICAL PROTEIN","Streptococcus pyogenes",4,"LEU A  60;MET A  49;LEU A  53;PRO A  92","None","0.92A","5u4sA-2ewcA:undetectable","5u4sA-2ewcA:21.05"]]