SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ewm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 PHE A  27
LEU A 220
ALA A 224
ALA A 228
LEU A   9
 None
 1.00A 1cbrA-2ewmA:
undetectable		 1cbrA-2ewmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 PHE A  27
LEU A 220
ALA A 224
ALA A 228
LEU A   9
 None
 1.00A 1cbrB-2ewmA:
undetectable		 1cbrB-2ewmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		4 / 8 ALA A  90
GLY A  15
ILE A  12
VAL A  63
 NAD  A 257 ( 4.0A)
None
None
NAD  A 257 (-3.4A)
 0.76A 1d4sB-2ewmA:
undetectable		 1d4sB-2ewmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		4 / 8 GLY A  15
ASN A  89
GLY A  14
VAL A 187
 None
NAD  A 257 (-3.8A)
NAD  A 257 (-3.3A)
NAD  A 257 (-4.1A)
 0.92A 1dbbH-2ewmA:
undetectable
1dbbL-2ewmA:
undetectable		 1dbbH-2ewmA:
23.33
1dbbL-2ewmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		3 / 3 ILE A 137
ILE A 182
THR A 178
 None
 0.33A 1rg7A-2ewmA:
2.4		 1rg7A-2ewmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		7 / 11 GLY A  14
ALA A  16
ASP A  38
LEU A  39
ASP A  62
VAL A  63
ALA A  90
 NAD  A 257 (-3.3A)
NAD  A 257 ( 3.7A)
NAD  A 257 (-2.8A)
NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.4A)
NAD  A 257 ( 4.0A)
 0.43A 1uayA-2ewmA:
27.6		 1uayA-2ewmA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		7 / 10 GLY A  14
ALA A  16
ASP A  38
LEU A  39
ASP A  62
VAL A  63
ALA A  90
 NAD  A 257 (-3.3A)
NAD  A 257 ( 3.7A)
NAD  A 257 (-2.8A)
NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.4A)
NAD  A 257 ( 4.0A)
 0.47A 1uayB-2ewmA:
28.6		 1uayB-2ewmA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 LEU A  39
ASP A  62
VAL A  63
ILE A 112
SER A 141
 NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.4A)
NAD  A 257 ( 4.3A)
NAD  A 257 (-3.1A)
 1.10A 1zq9A-2ewmA:
5.7		 1zq9A-2ewmA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 GLY A  14
LEU A  39
ASP A  62
VAL A  63
ILE A 112
 NAD  A 257 (-3.3A)
NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.4A)
NAD  A 257 ( 4.3A)
 0.69A 1zq9B-2ewmA:
2.5		 1zq9B-2ewmA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 GLY A  14
ASP A  38
ASP A  62
ASN A  89
ALA A  90
 NAD  A 257 (-3.3A)
NAD  A 257 (-2.8A)
NAD  A 257 (-3.5A)
NAD  A 257 (-3.8A)
NAD  A 257 ( 4.0A)
 0.92A 2bm9E-2ewmA:
5.1		 2bm9E-2ewmA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 8 ILE A  19
ILE A  23
ILE A  36
ARG A 135
ALA A  10
 NAD  A 257 (-3.9A)
None
None
None
None
 1.03A 2nniA-2ewmA:
undetectable		 2nniA-2ewmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 GLY A  14
ALA A  16
ALA A  22
LEU A  39
VAL A  63
 NAD  A 257 (-3.3A)
NAD  A 257 ( 3.7A)
None
NAD  A 257 (-4.1A)
NAD  A 257 (-3.4A)
 0.91A 2nyuA-2ewmA:
9.1		 2nyuA-2ewmA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 10 ILE A 162
ARG A 135
ALA A 232
LEU A 227
ALA A 224
 None
 1.25A 3lw5B-2ewmA:
undetectable		 3lw5B-2ewmA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 GLY A  14
ILE A  23
ASP A  38
LEU A  39
ASP A  62
 NAD  A 257 (-3.3A)
None
NAD  A 257 (-2.8A)
NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
 0.72A 3q87B-2ewmA:
6.8		 3q87B-2ewmA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 GLY A  20
GLY A  15
GLY A  14
LEU A 139
VAL A 187
 None
None
NAD  A 257 (-3.3A)
NAD  A 257 ( 4.6A)
NAD  A 257 (-4.1A)
 0.93A 4htfA-2ewmA:
8.0		 4htfA-2ewmA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 GLY A  20
GLY A  15
GLY A  14
LEU A 139
VAL A 187
 None
None
NAD  A 257 (-3.3A)
NAD  A 257 ( 4.6A)
NAD  A 257 (-4.1A)
 0.94A 4htfB-2ewmA:
7.0		 4htfB-2ewmA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 11 GLY A  14
GLY A  15
ASP A  38
LEU A  39
ASP A  62
 NAD  A 257 (-3.3A)
None
NAD  A 257 (-2.8A)
NAD  A 257 (-4.1A)
NAD  A 257 (-3.5A)
 0.61A 4pghA-2ewmA:
undetectable		 4pghA-2ewmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 11 GLY A  14
GLY A  15
ASP A  38
LEU A  39
VAL A  40
 NAD  A 257 (-3.3A)
None
NAD  A 257 (-2.8A)
NAD  A 257 (-4.1A)
NAD  A 257 ( 4.7A)
 0.59A 4pghA-2ewmA:
undetectable		 4pghA-2ewmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 8 ILE A  23
ASN A  88
VAL A 179
ILE A 177
PHE A  27
 None
 1.38A 4r38D-2ewmA:
undetectable		 4r38D-2ewmA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 12 LEU A  39
ASP A  38
GLY A  14
ALA A  90
ILE A  92
 NAD  A 257 (-4.1A)
NAD  A 257 (-2.8A)
NAD  A 257 (-3.3A)
NAD  A 257 ( 4.0A)
None
 0.99A 4xdrA-2ewmA:
undetectable		 4xdrA-2ewmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		3 / 3 ALA A  48
ASN A  51
LEU A  52
 None
 0.30A 5i1nB-2ewmA:
undetectable		 5i1nB-2ewmA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		3 / 3 ALA A  48
ASN A  51
LEU A  52
 None
 0.35A 5i1oA-2ewmA:
undetectable		 5i1oA-2ewmA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		3 / 3 ALA A  48
ASN A  51
LEU A  52
 None
 0.37A 5i1pA-2ewmA:
undetectable		 5i1pA-2ewmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		3 / 3 ALA A  48
ASN A  51
LEU A  52
 None
 0.45A 5i1pD-2ewmA:
undetectable		 5i1pD-2ewmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 9 PRO A 184
GLY A 244
SER A 141
VAL A 187
LEU A 186
 NAD  A 257 (-4.1A)
None
NAD  A 257 (-3.1A)
NAD  A 257 (-4.1A)
NAD  A 257 (-4.7A)
 1.32A 5o96E-2ewmA:
3.2
5o96F-2ewmA:
1.9		 5o96E-2ewmA:
21.17
5o96F-2ewmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE
(Azoarcus) 		5 / 11 ALA A  10
VAL A  87
THR A  13
ILE A  19
ALA A  45
 None
None
None
NAD  A 257 (-3.9A)
None
 1.16A 6h1lB-2ewmA:
undetectable		 6h1lB-2ewmA:
21.05