SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ewo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		4 / 6 LEU A 312
MET A 274
LEU A 320
ILE A  56
 None
 0.96A 1z95A-2ewoA:
undetectable		 1z95A-2ewoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 12 GLU A  22
GLY A 169
ASP A 168
ARG A 267
CYH A 204
 None
 1.30A 2bm9B-2ewoA:
undetectable		 2bm9B-2ewoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		6 / 12 GLY A 233
ALA A 227
VAL A 167
LEU A 174
LEU A 208
VAL A 210
 None
 1.20A 2yqzB-2ewoA:
undetectable		 2yqzB-2ewoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		4 / 6 GLY A 355
GLU A 218
GLY A 357
ASN A  37
 None
 0.85A 3e9rA-2ewoA:
undetectable		 3e9rA-2ewoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		4 / 6 GLY A 355
GLU A 218
GLY A 357
ASN A  37
 None
 0.85A 3e9rC-2ewoA:
undetectable		 3e9rC-2ewoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 9 ASP A 100
ILE A 362
GLY A 357
ILE A 305
PRO A 321
 None
 1.32A 3ekyB-2ewoA:
undetectable		 3ekyB-2ewoA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		3 / 3 TYR A 153
ASP A 112
ASP A  13
 None
 0.80A 3r24A-2ewoA:
undetectable		 3r24A-2ewoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 11 GLY A  19
ASP A 168
GLY A 169
MET A  17
CYH A 204
 None
 0.93A 4c5lA-2ewoA:
undetectable		 4c5lA-2ewoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 10 GLY A  19
ASP A 168
GLY A 169
MET A  17
CYH A 204
 None
 0.94A 4c5lC-2ewoA:
undetectable		 4c5lC-2ewoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 10 GLY A  19
ASP A 168
GLY A 169
MET A  17
CYH A 204
 None
 0.97A 4c5lD-2ewoA:
undetectable		 4c5lD-2ewoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 10 GLY A  19
ASP A 168
GLY A 169
MET A  17
CYH A 204
 None
 0.93A 4c5nD-2ewoA:
undetectable		 4c5nD-2ewoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		3 / 3 ASP A  95
TYR A 131
TRP A  38
 None
 1.17A 4p7nA-2ewoA:
undetectable		 4p7nA-2ewoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		3 / 3 GLU A 350
ARG A 348
GLN A 284
 None
 0.95A 4rtbA-2ewoA:
undetectable		 4rtbA-2ewoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		4 / 6 GLU A  20
PHE A  21
PHE A 229
HIS A 166
 None
 1.47A 4uciA-2ewoA:
undetectable		 4uciA-2ewoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 12 LEU A 160
ASN A 310
HIS A 360
LEU A  30
ILE A  98
 None
 1.10A 5dv4A-2ewoA:
undetectable		 5dv4A-2ewoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 12 ILE A 165
GLY A 163
ARG A  99
ASN A 186
THR A 155
 None
 1.02A 5fhzD-2ewoA:
2.8		 5fhzD-2ewoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		5 / 12 LEU A 330
CYH A 275
TYR A 239
PHE A 311
LEU A 320
 None
 1.40A 5kklB-2ewoA:
undetectable		 5kklB-2ewoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B2W_A_AG2A401_1
(PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		6 / 10 ASP A  95
TRP A  97
ASP A 100
TRP A 123
THR A 219
HIS A 222
 None
 0.76A 6b2wA-2ewoA:
43.5		 6b2wA-2ewoA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		3 / 3 PHE A  21
ARG A 231
ALA A 236
 None
 0.96A 6ecfB-2ewoA:
undetectable		 6ecfB-2ewoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2ewo PUTATIVE AGMATINE
DEIMINASE
(Streptococcus
mutans) 		4 / 4 LEU A 106
ASP A  13
PRO A  10
ARG A 114
 None
 1.15A 6fgdA-2ewoA:
2.5		 6fgdA-2ewoA:
21.43