SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ex5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 2ex5 DNA ENDONUCLEASE
I-CEUI
(Chlamydomonas
moewusii) 		5 / 12 VAL A  95
GLY A  97
ILE A 113
LEU A  43
ILE A  23
 None
 1.16A 3ijdB-2ex5A:
undetectable		 3ijdB-2ex5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2ex5 DNA ENDONUCLEASE
I-CEUI
(Chlamydomonas
moewusii) 		5 / 12 LEU A 123
LYS A  21
TYR A  36
LEU A 105
LEU A  37
 None
 1.21A 4l9qB-2ex5A:
undetectable		 4l9qB-2ex5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ex5 DNA ENDONUCLEASE
I-CEUI
(Chlamydomonas
moewusii) 		4 / 7 GLU A  18
ARG A 112
LEU A 105
ILE A  23
 None
 0.88A 4xumA-2ex5A:
undetectable		 4xumA-2ex5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 2ex5 DNA ENDONUCLEASE
I-CEUI
(Chlamydomonas
moewusii) 		5 / 12 LEU A 125
LEU A 123
ILE A  23
LEU A  20
LEU A  37
 None
 1.15A 5toaB-2ex5A:
undetectable		 5toaB-2ex5A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2ex5 DNA ENDONUCLEASE
I-CEUI
(Chlamydomonas
moewusii) 		4 / 5 PRO A   8
GLY A   9
ASN A 120
LYS A  11
 None
 1.14A 5x23A-2ex5A:
undetectable		 5x23A-2ex5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2ex5 DNA ENDONUCLEASE
I-CEUI
(Chlamydomonas
moewusii) 		5 / 12 VAL A 107
PHE A 140
PHE A  89
TYR A 141
ILE A 138
 None
 1.44A 6mxtA-2ex5A:
0.9		 6mxtA-2ex5A:
20.51