SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2exh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 HIS A 341
ASN A 340
ASP A 327
LEU A  51
 MES  A2005 (-3.9A)
None
None
MES  A2005 ( 4.7A)
 0.95A 1e7cA-2exhA:
undetectable		 1e7cA-2exhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A  30
VAL A  73
ASN A 104
ASP A 128
 None
 1.25A 1hwiB-2exhA:
undetectable		 1hwiB-2exhA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A  30
VAL A  73
ASN A 104
ASP A 128
 None
 1.27A 1hwkA-2exhA:
undetectable		 1hwkA-2exhA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A  30
VAL A  73
ASN A 104
ASP A 128
 None
 1.24A 1hwkC-2exhA:
undetectable		 1hwkC-2exhA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A  30
VAL A  73
ASN A 104
ASP A 128
 None
 1.24A 1hwkD-2exhA:
undetectable		 1hwkD-2exhA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 127
PHE A 506
PHE A  32
HIS A 211
 None
 0.93A 1lh6A-2exhA:
undetectable		 1lh6A-2exhA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 433
PRO A 455
VAL A 454
ILE A 452
 None
 0.84A 2aoiB-2exhA:
undetectable		 2aoiB-2exhA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 479
SER A 477
TYR A 462
TYR A 529
 None
 1.36A 2bteD-2exhA:
undetectable		 2bteD-2exhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A  41
ILE A  27
ARG A 384
GLY A  11
 None
 1.18A 2du8G-2exhA:
undetectable		 2du8G-2exhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A  41
ILE A  27
ARG A 384
GLY A  11
 None
 1.16A 2du8J-2exhA:
undetectable		 2du8J-2exhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A 301
LEU A 191
ARG A 217
GLY A 196
 None
 1.04A 2hs2B-2exhA:
undetectable		 2hs2B-2exhA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 468
LYS A 473
VAL A 465
 None
 0.92A 2jfaB-2exhA:
undetectable		 2jfaB-2exhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 479
SER A 477
TYR A 462
TYR A 529
 None
 1.39A 2v0gA-2exhA:
undetectable		 2v0gA-2exhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 427
GLN A 404
ARG A 516
 None
 0.99A 2w3bB-2exhA:
undetectable		 2w3bB-2exhA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 THR A 394
VAL A 396
SER A 406
VAL A 410
GLY A 512
 None
 1.48A 2x2iD-2exhA:
undetectable		 2x2iD-2exhA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 496
THR A 507
PHE A 380
 None
 0.72A 2x91A-2exhA:
undetectable		 2x91A-2exhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 289
TYR A 532
ARG A 268
PHE A 388
 None
 1.04A 3mjrD-2exhA:
undetectable		 3mjrD-2exhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 PHE A 334
PHE A 530
PHE A 343
ALA A 382
LEU A 366
 None
 1.50A 3t3sA-2exhA:
0.0		 3t3sA-2exhA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 378
PHE A 380
TYR A 412
 None
 0.99A 3ucjB-2exhA:
undetectable		 3ucjB-2exhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 378
PHE A 380
TYR A 412
 None
 1.01A 3ucjA-2exhA:
undetectable		 3ucjA-2exhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 221
LEU A 170
TYR A 140
PRO A 174
ASP A 128
 None
 1.20A 4j7xJ-2exhA:
undetectable		 4j7xJ-2exhA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 247
GLY A 248
ASP A  15
ASN A 210
GLY A 309
 None
 1.04A 4obwB-2exhA:
undetectable		 4obwB-2exhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 191
VAL A 142
PRO A 189
THR A 202
GLY A 205
 None
 1.21A 4q15A-2exhA:
undetectable		 4q15A-2exhA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 191
VAL A 142
PRO A 189
THR A 202
GLY A 205
 None
 1.25A 4q15B-2exhA:
undetectable		 4q15B-2exhA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A 291
THR A 290
GLY A 248
ALA A 247
SER A 236
 None
 1.03A 4qvlK-2exhA:
undetectable
4qvlL-2exhA:
undetectable		 4qvlK-2exhA:
17.77
4qvlL-2exhA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A 291
THR A 290
GLY A 248
ALA A 247
SER A 236
 None
 1.01A 4qvlY-2exhA:
undetectable
4qvlZ-2exhA:
undetectable		 4qvlY-2exhA:
17.77
4qvlZ-2exhA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 291
THR A 290
GLY A 248
ALA A 247
SER A 236
 None
 1.04A 4qvmY-2exhA:
undetectable
4qvmZ-2exhA:
undetectable		 4qvmY-2exhA:
17.77
4qvmZ-2exhA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A  62
ASP A 118
ILE A  65
 GOL  A2008 ( 4.8A)
None
None
 0.63A 4xi3D-2exhA:
undetectable		 4xi3D-2exhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A 291
THR A 290
GLY A 248
ALA A 247
SER A 236
 None
 1.03A 5bxnY-2exhA:
undetectable
5bxnZ-2exhA:
undetectable		 5bxnY-2exhA:
17.77
5bxnZ-2exhA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 PRO A 349
GLY A  37
PHE A  35
ASP A  91
LEU A  59
 None
None
None
GOL  A2008 (-3.4A)
None
 1.34A 5eeiB-2exhA:
undetectable		 5eeiB-2exhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 264
LEU A 265
SER A 236
THR A  10
PRO A 243
 None
 1.28A 5hnxB-2exhA:
undetectable		 5hnxB-2exhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 191
VAL A 142
PRO A 189
THR A 202
GLY A 205
 None
 1.24A 5xipA-2exhA:
undetectable		 5xipA-2exhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 191
VAL A 142
PRO A 189
THR A 202
GLY A 205
 None
 1.23A 5xipC-2exhA:
undetectable		 5xipC-2exhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLN A 293
ASN A   6
PRO A   7
ILE A   8
 None
 0.97A 6hzpA-2exhA:
undetectable		 6hzpA-2exhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2exh BETA-D-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 309
ASN A   6
GLU A 289
GLY A 267
 None
 0.95A 6n7fA-2exhA:
undetectable		 6n7fA-2exhA:
9.25