SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2exr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 LEU A 442
VAL A 408
VAL A 312
VAL A 280
 None
 0.93A 1iwiA-2exrA:
undetectable		 1iwiA-2exrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.89A 1rtsB-2exrA:
undetectable		 1rtsB-2exrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 LEU A 442
VAL A 408
VAL A 312
VAL A 280
 None
 0.91A 1t86A-2exrA:
undetectable		 1t86A-2exrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 9 PHE A 437
VAL A 177
GLY A 176
VAL A 428
ILE A 430
 None
FAD  A 525 (-4.1A)
FAD  A 525 (-3.5A)
None
None
 1.26A 2a1oB-2exrA:
undetectable		 2a1oB-2exrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 11 ARG A  83
VAL A  66
ALA A  64
LEU A 108
SER A  84
 None
 1.16A 2bxgA-2exrA:
undetectable		 2bxgA-2exrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		3 / 3 ARG A 349
ASP A 258
ASP A 253
 None
 0.79A 2ejtA-2exrA:
undetectable		 2ejtA-2exrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.87A 2tsrB-2exrA:
undetectable		 2tsrB-2exrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 6 LEU A 442
VAL A 408
VAL A 312
VAL A 280
 None
 0.92A 2z97A-2exrA:
undetectable		 2z97A-2exrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 6 THR A 167
ILE A 228
SER A 173
LEU A 172
 FAD  A 525 (-3.1A)
FAD  A 525 (-4.0A)
FAD  A 525 (-3.1A)
None
 0.96A 3deuB-2exrA:
undetectable		 3deuB-2exrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 11 CYH A 149
LEU A 146
LEU A 235
ALA A 156
ASN A 190
 None
 1.26A 3e22D-2exrA:
undetectable		 3e22D-2exrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 5 PRO A  71
THR A 167
VAL A 168
GLY A 169
 None
FAD  A 525 (-3.1A)
None
FAD  A 525 (-3.5A)
 1.06A 3elzA-2exrA:
undetectable		 3elzA-2exrA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 LEU A  87
GLY A 201
ALA A  75
ILE A  36
 None
 0.80A 3jusB-2exrA:
undetectable		 3jusB-2exrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 12 ARG A 499
PRO A 186
GLY A 169
LEU A 194
ILE A 228
 None
None
FAD  A 525 (-3.5A)
None
FAD  A 525 (-4.0A)
 0.99A 3ku1H-2exrA:
undetectable		 3ku1H-2exrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		3 / 3 TYR A 476
TYR A 483
GLU A 432
 None
 0.91A 3pfgA-2exrA:
undetectable		 3pfgA-2exrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 LEU A 360
GLN A 180
TYR A 356
PHE A 359
 None
 1.13A 3po7A-2exrA:
undetectable		 3po7A-2exrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 12 GLY A  93
GLY A 170
THR A 171
VAL A 109
GLY A  95
 FAD  A 525 (-3.5A)
FAD  A 525 (-3.4A)
FAD  A 525 ( 4.7A)
None
FAD  A 525 (-3.8A)
 1.05A 3sglA-2exrA:
undetectable		 3sglA-2exrA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 5 LEU A 222
GLY A 223
PHE A 225
PHE A 500
 None
FAD  A 525 (-3.6A)
None
None
 1.18A 3smtA-2exrA:
undetectable		 3smtA-2exrA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 PRO A 157
ARG A 158
GLY A 185
PRO A 186
 None
 1.36A 3ucbB-2exrA:
undetectable		 3ucbB-2exrA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 10 ASP A  73
VAL A  66
GLY A  76
ALA A  77
ALA A  80
 None
 1.03A 3ucjA-2exrA:
undetectable		 3ucjA-2exrA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 10 ASP A  73
VAL A  66
GLY A  76
ALA A  77
ALA A  80
 None
 1.02A 3ucjB-2exrA:
undetectable		 3ucjB-2exrA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 GLY A 185
PHE A 386
PHE A 437
LEU A 417
 None
 0.88A 3v7pA-2exrA:
undetectable		 3v7pA-2exrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 9 ASP A  73
ILE A  74
GLY A  70
THR A 229
GLY A 138
 None
None
None
None
FAD  A 525 ( 4.4A)
 0.95A 4acaB-2exrA:
undetectable
4acaC-2exrA:
undetectable		 4acaB-2exrA:
22.51
4acaC-2exrA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 THR A 229
ILE A  74
VAL A  78
GLY A 226
 None
 0.92A 4eq4B-2exrA:
undetectable		 4eq4B-2exrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.86A 4iqqA-2exrA:
undetectable		 4iqqA-2exrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.80A 4iqqD-2exrA:
undetectable		 4iqqD-2exrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 10 PHE A 386
TYR A 479
GLY A 220
THR A 426
ILE A 430
 None
FAD  A 525 (-4.5A)
None
None
None
 1.17A 4jx1B-2exrA:
undetectable		 4jx1B-2exrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 GLN A 517
PRO A 515
ILE A  98
ASP A  53
 FAD  A 525 (-3.9A)
None
None
None
 1.04A 4pcuA-2exrA:
undetectable		 4pcuA-2exrA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 11 GLY A 138
GLY A 139
VAL A 145
ASP A 135
ILE A 228
 FAD  A 525 ( 4.4A)
None
None
None
FAD  A 525 (-4.0A)
 0.96A 4pghA-2exrA:
undetectable		 4pghA-2exrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 THR A 188
GLY A 220
GLY A 221
VAL A 218
 None
 0.81A 4qvvK-2exrA:
undetectable
4qvvL-2exrA:
undetectable		 4qvvK-2exrA:
16.86
4qvvL-2exrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 THR A 188
GLY A 220
GLY A 221
VAL A 218
 None
 0.81A 4qvvY-2exrA:
undetectable
4qvvZ-2exrA:
undetectable		 4qvvY-2exrA:
16.86
4qvvZ-2exrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 5 PHE A 400
PHE A 255
PHE A 252
VAL A 414
 None
 1.12A 5a1rA-2exrA:
undetectable		 5a1rA-2exrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 9 VAL A 177
TYR A 415
ILE A 439
LEU A 443
TYR A 479
 FAD  A 525 (-4.1A)
None
None
None
FAD  A 525 (-4.5A)
 1.15A 5fxfA-2exrA:
12.3		 5fxfA-2exrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 5 GLY A 176
PRO A 157
THR A 161
THR A 188
 FAD  A 525 (-3.5A)
None
FAD  A 525 (-4.1A)
None
 1.00A 5h5fA-2exrA:
undetectable		 5h5fA-2exrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 12 GLY A 276
ALA A 181
SER A 388
ILE A 392
PHE A 395
 None
 1.25A 5ih0A-2exrA:
undetectable		 5ih0A-2exrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 GLY A  70
VAL A 203
ASP A 195
VAL A 197
 None
 0.78A 5ik1A-2exrA:
undetectable		 5ik1A-2exrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		5 / 11 GLN A  37
ASN A 118
VAL A  66
THR A 115
LEU A  34
 None
 1.43A 5jh7D-2exrA:
undetectable		 5jh7D-2exrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.89A 5nooB-2exrA:
undetectable		 5nooB-2exrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 8 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.89A 5nooD-2exrA:
undetectable		 5nooD-2exrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 7 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.89A 5x5qC-2exrA:
undetectable		 5x5qC-2exrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2exr CYTOKININ
DEHYDROGENASE 7
(Arabidopsis
thaliana) 		4 / 6 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.91A 5x5qE-2exrA:
undetectable		 5x5qE-2exrA:
20.04